Document Detail


Smaller age-associated reductions in leg venous compliance in endurance exercise-trained men.
MedLine Citation:
PMID:  11514296     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined the independent and interactive influences of aging and habitual endurance exercise on calf venous compliance in humans. We tested the hypotheses that calf venous compliance is 1) reduced with age in sedentary and endurance-trained men, and 2) elevated in young and older endurance-trained compared with age-matched sedentary men. We studied 8 young (28 +/- 1 yr) and 8 older (65 +/- 1) sedentary, and 8 young (27 +/- 1) and 8 older (63 +/- 2) endurance-trained men. Calf venous compliance was measured in supine subjects by inflating a venous collecting cuff, placed above the knee, to 60 mmHg for 8 min and then decreasing cuff pressure at 1 mmHg/s to 0 mmHg. Calf venous compliance was determined using the first derivative of the pressure-volume relation during cuff pressure reduction (compliance = beta(1) + 2. beta(2). cuff pressure). Calf venous compliance was reduced with age in sedentary (approximately 40%) and endurance-trained men (approximately 20%) (both P < 0.01). Furthermore, calf venous compliance was approximately 70-120% greater in endurance-trained compared with age-matched sedentary men and approximately 30% greater in older endurance-trained compared with young sedentary men (both P < 0.01). These data indicate that calf venous compliance is reduced with age in sedentary and endurance-trained men, but compliance is better preserved in endurance-trained men.
Authors:
K D Monahan; F A Dinenno; D R Seals; J R Halliwill
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  281     ISSN:  0363-6135     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-08-21     Completed Date:  2001-09-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1267-73     Citation Subset:  IM; S    
Affiliation:
Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, Colorado 80309, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / physiology*
Blood Pressure / physiology
Compliance
Exercise / physiology*
Humans
Leg / blood supply*,  physiology*
Male
Middle Aged
Oxygen Consumption / physiology
Plethysmography
Posture / physiology
Running / physiology
Veins / physiology*
Grant Support
ID/Acronym/Agency:
AG-06537/AG/NIA NIH HHS; AG-13038/AG/NIA NIH HHS; AG-16071/AG/NIA NIH HHS; NS-32352/NS/NINDS NIH HHS

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