Document Detail

Small-vessel vasculitis surrounding an uninflamed temporal artery and isolated vasa vasorum vasculits of the temporal artery: Two subsets of giant cell arteritis.
MedLine Citation:
PMID:  21953306     Owner:  NLM     Status:  Publisher    
OBJECTIVE.: To evaluate the frequency and clinical characteristics of patients with periadventitial small-vessel vasculitis (SVV) and isolated vasa vasorum vasculitis (VVV). METHODS.: We identified 455 temporal artery biopsy (TAB) performed in Reggio Emilia (Italy) residents between 1986 and 2003. Slides of TAB specimens were reviewed by one Pathologist blinded to clinical data. SVV was defined as inflammation of the small vessels external to the TA adventitia, and VVV as isolated inflammation of TA vasa vasorum. Medical records of patients with SVV and/or VVV were reviewed and demographic, clinical, laboratory, and follow-up data were collected. For comparison purposes, we collected the same data from an equal number of randomly selected patients with evidence of classic giant cell arteritis (GCA). RESULTS.: 16 patients showed SVV, 18 isolated VVV, and 5 associated SVV and VVV. Comparing the patients with SVV with those with classic GCA, the frequencies of headache, scalp tenderness, abnormalities of temporal arteries, jaw claudication, anorexia and weight loss, acute phase reactant levels at diagnosis, as well as initial and cumulative prednisone dosages were significantly lower in the patients with SVV, while the frequency of peripheral synovitis was higher and the frequency of cranial ischemic events was similar in the two groups. In contrast, the clinical characteristics and ESR values at diagnosis of patients with isolated VVV were similar to those of patients with classic GCA. CONCLUSIONS.: Isolated VVV and SVV should be considered part of the histopathological spectrum of GCA. © 2011 American College of Rheumatology.
Giovanna Restuccia; Alberto Cavazza; Luigi Boiardi; Nicolò Pipitone; Pierluigi Macchioni; Gianluigi Bajocchi; Maria Grazia Catanoso; Francesco Muratore; Alessandra Ghinoi; Luca Magnani; Luca Cimino; Carlo Salvarani
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-27
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  -     ISSN:  1529-0131     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 by the American College of Rheumatology.
Unità Operativa di Reumatologia, *Dipartimento di Anatomia Patologica, and **Unità Operativa di Oculistica, Arcispedale S. Maria Nuova, Reggio Emilia; ITALY.
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