| Small size-specific umbilical vein diameter in severe growth restricted fetuses that die in utero. | |
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MedLine Citation:
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PMID: 18821714 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To study changes in umbilical vein (UV) blood flow velocity, diameter and blood flow volume in intrauterine growth retardation (IUGR) fetuses who die in utero (IUD-IUGR). METHODS: Twelve singleton IUGR fetuses who died in utero below 600 g were included. All cases had abnormal uterine and umbilical arteries PI. UV diameter and velocity were measured at the time of diagnosis, and at the last exam, within 24 hours prior to intrauterine death. UV flow was calculated per unit weight (mL/min/kg) and abdominal circumference (AC) (mL/min/cm). UV diameter and velocity were normalized per unit AC. Findings were compared to 14 severe viable-IUGR and 22 normal gestational age-matched fetuses. RESULTS: UV flow (mL/min/kg) was significantly lower in IUD-IUGR compared to viable-IUGR (87 +/- 30 mL/min/kg) and control fetuses (131 +/- 33 mL/min/kg) both at the first (79 +/- 40 mL/min/kg) (P < 0.0001), and at the last exam (54 +/- 29 mL/min/kg) (P < 0.0001). No significant longitudinal flow changes were observed. UV velocity/AC was significantly reduced both in IUD-IUGR and viable-IUGR compared to normal fetuses. UV diameter/AC, was significantly reduced only in IUD-IUGR and not in viable-IUGR compared to normal fetuses. CONCLUSIONS: UV flow (mL/min/kg) was significantly lower in IUD-IUGR fetuses both versus viable-IUGR and normal fetuses. A low flow was due to a decreased UV flow velocity, but also due to a reduced vessel size. This significantly smaller UV size observed in IUGR fetuses with the worst outcome could be considered a severe prognostic sign because of the diagnosis of severe growth restriction. |
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Authors:
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Serena Rigano; Maddalena Bozzo; Alessandra Padoan; Paola Mustoni; Maria Bellotti; Henry L Galan; Enrico Ferrazzi |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Prenatal diagnosis Volume: 28 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-06 Completed Date: 2009-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 908-13 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Obstetrics and Gynecology at DSC L. Sacco, University of Milan, Milan, Italy. serena.rigano@unimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Flow Velocity Female Fetal Death / physiopathology*, ultrasonography Fetal Growth Retardation / physiopathology*, ultrasonography Fetus / blood supply*, physiopathology Humans Pregnancy Retrospective Studies Ultrasonography, Doppler, Pulsed Ultrasonography, Prenatal Umbilical Arteries / physiopathology, ultrasonography Umbilical Veins / physiopathology*, ultrasonography |
| Grant Support | |
ID/Acronym/Agency:
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5R01 HD 034837-07/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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