Document Detail

Small size for gestational age and the risk for infant mortality in the subsequent pregnancy.
MedLine Citation:
PMID:  22858049     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine the association between small for gestational age (SGA) in the first pregnancy and risk for infant mortality in the second pregnancy.
METHODS: This is a population-based, retrospective cohort study in which we used the Missouri maternally linked cohort dataset for 1978-2005. Analyses were restricted to women who had two singleton pregnancies during the study period. The exposure was SGA in the first pregnancy, whereas the primary outcome was infant mortality in the second pregnancy. Kaplan-Meier Estimate and Cox proportional hazard regression were conducted.
RESULTS: Infant mortality was significantly greater among mothers with previous SGA (P < .01). A persistent association of previous SGA with subsequent infant mortality was observed (adjusted hazard ratio [AHR] 1.35, 95% confidence interval [95% CI] 1.24-1.48). Race-specific data illustrated that black women with a previous SGA birth were 40% more likely to experience infant mortality (AHR 1.40, 95% CI 1.21-1.63) than their counterparts without a history of SGA, but white women with a previous SGA had an increased risk of 31% (AHR 1.31, 95% CI 1.17-1.46).
CONCLUSIONS: Women with previous SGA bear increased risks for subsequent infant mortality, which was greater among black mothers. Hence, SGA plays an important role in the black-white disparity in infant mortality. Women's previous childbearing experiences could serve as important criterion in determining appropriate interconception strategies to improve infant health and survival.
Hamisu M Salihu; Abraham Salinas; Euna M August; Mulubrhan F Mogos; Hanna Weldeselasse; Valerie E Whiteman
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Publication Detail:
Type:  Journal Article     Date:  2012-08-02
Journal Detail:
Title:  Annals of epidemiology     Volume:  22     ISSN:  1873-2585     ISO Abbreviation:  Ann Epidemiol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-02-12     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, College of Medicine, University of South Florida, Tampa, FL 33612, USA.
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MeSH Terms
Birth Certificates
Death Certificates
Ethnic Groups / statistics & numerical data*
Infant Mortality / ethnology*
Infant, Newborn
Infant, Small for Gestational Age*
Likelihood Functions
Maternal Age
Missouri / epidemiology
Population Surveillance
Pregnancy Outcome / ethnology*
Retrospective Studies
Risk Factors
Socioeconomic Factors
Young Adult
Grant Support

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