| Small pulmonary arteries in some natives of La Paz, Bolivia. | |
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MedLine Citation:
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PMID: 7314035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A histological study was made of the small pulmonary blood vessels in pieces of lung obtained at necropsy from 19 long-term residents of La Paz, Bolivia (3800 m). There was variation in the response of the pulmonary vasculature of these subjects to the chronic hypoxia of high altitude. The most characteristic finding, seen in seven of the 16 cases beyond infancy, was distal extension of vascular smooth muscle into pulmonary arterioles as small as 20 micrometer in diameter. Medial hypertrophy of the muscular pulmonary arteries occurred in only three of these seven subjects. Intimal fibrosis was seen in eight of the 19 cases and was ascribed to age; such fibrotic proliferation may affect the reversibility of hypoxic pulmonary hypertension and associated vascular changes in highlanders. |
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Authors:
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D Heath; P Smith; J Rios Dalenz; D Williams; P Harris |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Thorax Volume: 36 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1982-02-22 Completed Date: 1982-02-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 599-604 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Altitude* Arteries / pathology Arterioles / pathology Bolivia Child, Preschool Ethnic Groups Female Humans Hypertrophy / pathology Infant Lung / blood supply* Male Middle Aged Muscle, Smooth, Vascular / pathology |
| Comments/Corrections | |
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