| Small peripheral pulmonary carcinomas evaluated with dynamic MR imaging: correlation with tumor vascularity and prognosis. | |
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MedLine Citation:
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PMID: 12714678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To correlate the findings at contrast material-enhanced dynamic magnetic resonance (MR) imaging of small peripheral pulmonary carcinomas with tumor vascularity and prognosis. MATERIALS AND METHODS: Ninety-four patients with small peripheral pulmonary carcinomas who underwent surgical resection were examined retrospectively. Pathologic specimens were stained with hematoxylin-eosin and elastin-van Gieson. CD34 and vascular endothelial growth factor (VEGF) were assessed immunohistochemically. Delineated CD34-positive cells were counted as microvessels. Dynamic MR imaging was performed prior to and at 1, 2, 3, 4, 5, 6, and 8 minutes after injection of a bolus of gadopentetate dimeglumine. The two observers reviewed all images, and two pathologists performed all histologic analyses; a decision was determined with consensus. The maximum enhancement ratio (MER), the time lapse between the completion of the injection and the point of maximum signal intensity (Tmax), the washout ratio, and the slope value of the time-signal intensity curve were correlated with the microvessel density. VEGF-positive and VEGF-negative tumors were compared. All statistical analyses were performed by using nonparametric methods. RESULTS: The MER and the slope value were positively correlated, and the Tmax was negatively correlated (Spearman rank test, P <.0001, all comparisons) with the microvessel counts. The distribution of elastic and collagen fibers correlated with the washout ratio (Kruskal-Wallis test, P <.001). There was a statistically significant difference between the slope value of VEGF-positive tumors and that of VEGF-negative tumors (Mann-Whitney U test, P <.0001). Patients with VEGF-positive tumors had a significantly shorter overall survival than did those with VEGF-negative tumors (log-rank test, P <.0001). CONCLUSION: Dynamic MR imaging findings correlate with tumor vascularity and may be helpful in the prediction of prognosis. |
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Authors:
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Kiminori Fujimoto; Toshi Abe; Nestor L Müller; Hiroshi Terasaki; Seiya Kato; Junko Sadohara; Rei Kono; Osamu Edamitsu; Tatsuya Ishitake; Akihiro Hayashi; Toru Rikimaru; Naofumi Hayabuchi |
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Publication Detail:
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Type: Journal Article Date: 2003-04-24 |
Journal Detail:
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Title: Radiology Volume: 227 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-05-29 Completed Date: 2003-06-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 786-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan. kimichan@med.kurume-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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blood supply,
mortality,
pathology* Aged Carcinoma, Squamous Cell / blood supply, mortality, pathology* Contrast Media Endothelial Growth Factors / analysis Female Gadolinium DTPA / diagnostic use Humans Intercellular Signaling Peptides and Proteins / analysis Lung Neoplasms / blood supply, mortality, pathology* Lymphokines / analysis Magnetic Resonance Imaging* Male Prognosis Protein Isoforms / analysis Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Endothelial Growth Factors; 0/Intercellular Signaling Peptides and Proteins; 0/Lymphokines; 0/Protein Isoforms; 0/Vascular Endothelial Growth Factor A; 0/Vascular Endothelial Growth Factors; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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