Document Detail

Small molecules in cellular reprogramming and differentiation.
MedLine Citation:
PMID:  21141734     Owner:  NLM     Status:  MEDLINE    
Recent advances in somatic cell reprogramming and directed differentiation make it possible to generate patient-specific pluripotent cells and further derive functional tissue-specific cells for biomedical research and future therapies. Chemical compounds targeting enzymes or signaling proteins are powerful tools to regulate and reveal complex cellular processes and have been identified and applied to controlling cell fate and function, including stem cell maintenance, differentiation, and reprogramming. Not only are small molecules useful in generating desired cell types in vitro for various applications, but also such small molecules could be further developed as conventional therapeutics to target patient's own cells residing in different tissues/organs for treating degenerative diseases, injuries, and cancer. Here, we will review recent studies of small molecules in controlling cell fate.
Xu Yuan; Wenlin Li; Sheng Ding
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques     Volume:  67     ISSN:  0071-786X     ISO Abbreviation:  Prog Drug Res     Publication Date:  2011  
Date Detail:
Created Date:  2010-12-14     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1304021     Medline TA:  Prog Drug Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  253-66     Citation Subset:  IM    
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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MeSH Terms
Cell Differentiation*
Endoderm / physiology
Epigenesis, Genetic
Neoplasms / etiology
Nuclear Reprogramming*
Pluripotent Stem Cells / cytology

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