| Small molecules in cellular reprogramming and differentiation. | |
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MedLine Citation:
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PMID: 21141734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent advances in somatic cell reprogramming and directed differentiation make it possible to generate patient-specific pluripotent cells and further derive functional tissue-specific cells for biomedical research and future therapies. Chemical compounds targeting enzymes or signaling proteins are powerful tools to regulate and reveal complex cellular processes and have been identified and applied to controlling cell fate and function, including stem cell maintenance, differentiation, and reprogramming. Not only are small molecules useful in generating desired cell types in vitro for various applications, but also such small molecules could be further developed as conventional therapeutics to target patient's own cells residing in different tissues/organs for treating degenerative diseases, injuries, and cancer. Here, we will review recent studies of small molecules in controlling cell fate. |
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Authors:
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Xu Yuan; Wenlin Li; Sheng Ding |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Progress in drug research. Fortschritte der Arzneimittelforschung. Progrès des recherches pharmaceutiques Volume: 67 ISSN: 0071-786X ISO Abbreviation: Prog Drug Res Publication Date: 2011 |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1304021 Medline TA: Prog Drug Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 253-66 Citation Subset: IM |
Affiliation:
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Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation* Endoderm / physiology Epigenesis, Genetic Humans Neoplasms / etiology Nuclear Reprogramming* Pluripotent Stem Cells / cytology |
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