| Small-molecule inhibitor of Vibrio cholerae virulence and intestinal colonization. | |
| | |
MedLine Citation:
|
PMID: 16223984 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Increasing antibiotic resistance requires the development of new approaches to combating infection. Virulence gene expression in vivo represents a target for antibiotic discovery that has not yet been explored. A high-throughput, phenotypic screen was used to identify a small molecule 4-[N-(1,8-naphthalimide)]-n-butyric acid, virstatin, that inhibits virulence regulation in Vibrio cholerae. By inhibiting the transcriptional regulator ToxT, virstatin prevents expression of two critical V. cholerae virulence factors, cholera toxin and the toxin coregulated pilus. Orogastric administration of virstatin protects infant mice from intestinal colonization by V. cholerae. |
| | |
Authors:
|
Deborah T Hung; Elizabeth A Shakhnovich; Emily Pierson; John J Mekalanos |
Related Documents
:
|
3781714 - Preventable causes of death versus infant mortality as an indicator of the quality of h... 3061704 - Rickets of prematurity: controversies in causation and prevention. 21254284 - Risks of congenital malformations and perinatal events among infants exposed to calcium... 21159164 - Behavioural symptoms of attention deficit/hyperactivity disorder in preterm and term ch... 22696334 - Bronchodilators for the prevention and treatment of chronic lung disease in preterm inf... 2712854 - Audiologic screening of newborn infants who are at risk for hearing impairment. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. Date: 2005-10-13 |
Journal Detail:
|
Title: Science (New York, N.Y.) Volume: 310 ISSN: 1095-9203 ISO Abbreviation: Science Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-10-28 Completed Date: 2005-11-23 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0404511 Medline TA: Science Country: United States |
Other Details:
|
Languages: eng Pagination: 670-4 Citation Subset: IM |
Affiliation:
|
Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. dhung@partners.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Bacterial Agents / pharmacology* Bacterial Proteins / biosynthesis, drug effects Butyric Acids / pharmacology* Cell Line Cholera / microbiology Cholera Toxin / biosynthesis Fimbriae, Bacterial / drug effects Gene Expression Regulation, Bacterial / drug effects Intestine, Small / microbiology* Mice Microbial Sensitivity Tests Naphthalenes / pharmacology* Naphthalimides Transcription Factors / biosynthesis, drug effects Vibrio cholerae / drug effects*, pathogenicity Virulence / drug effects Virulence Factors / biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
|
AI26289/AI/NIAID NIH HHS; K08 AI060708-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents; 0/Bacterial Proteins; 0/Butyric Acids; 0/Naphthalenes; 0/Naphthalimides; 0/Transcription Factors; 0/Virulence Factors; 0/virstatin; 147979-50-8/tcpN protein, Vibrio cholerae; 9012-63-9/Cholera Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension.
Next Document: The mid-Pleistocene transition in the tropical Pacific.