Document Detail

Small-molecule compounds that modulate lipolysis in adipose tissue: targeting strategies and molecular classes.
MedLine Citation:
PMID:  17052606     Owner:  NLM     Status:  MEDLINE    
Lipolysis is an important pathway in maintaining energy homeostasis through the degradation of triglycerides in adipose tissue and the release of fatty acids into the circulation as an energy source. However, an elevated level of circulating fatty acids leads to unfavorable metabolic effects such as insulin resistance and dyslipidemia. Cell surface receptors and intracellular components of the lipolytic pathway have been targeted to develop antilipolytic agents, among which are G-protein-coupled receptor agonists and lipase inhibitors. In addition, molecules that stimulate lipolysis have been tested in clinical trials as a treatment for obesity. Together, these molecules represent a diverse group of regulators for this pathway. This review will discuss strategies to target lipolysis and the major issues with representative small-molecule modulators of this pathway.
Minghan Wang; Christopher Fotsch
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Chemistry & biology     Volume:  13     ISSN:  1074-5521     ISO Abbreviation:  Chem. Biol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-20     Completed Date:  2006-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9500160     Medline TA:  Chem Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1019-27     Citation Subset:  IM    
Department of Metabolic Disorders, Amgen Incorporated, Thousand Oaks, California 91320, USA. <>
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MeSH Terms
Adipose Tissue / drug effects*,  metabolism*
Insulin / pharmacology
Lipolysis / drug effects*
Molecular Structure
Molecular Weight
Niacin / analogs & derivatives,  chemistry,  pharmacology*
Reg. No./Substance:
11061-68-0/Insulin; 59-67-6/Niacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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