| Small lesions detectability with the Biograph 16 Hi-Rez PET/CT scanner and fast imaging protocols: performance evaluation using an anthropomorphic thoracic phantom and ROC analyses. | |
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MedLine Citation:
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PMID: 21061189 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: The purpose of this study was to evaluate the impact on lesion detectability of fast imaging protocols using 18F-FDG and a 3-dimensional LSO-based PET/CT scanner. METHODS: An anthropomorphic thoracic phantom was used simulating the anatomical structures of radioactivity distribution for the upper torso of an underweight patient. Irregularly shaped targets of small dimensions, the zeolites, were located inside the phantom in an unpredictable position for the observers. Target-to background ratios and target dimensions were selected in order to sample the range of detectability. Repeated imaging was performed to acquire PET images with varying emission scan duration (ESD) of 1, 2, 3 and 4 min/bed and background activity concentrations of 10, 5 and 3 kBq/mL in the torso cavity. Three observers ranked the targets and a receiver operating characteristic analysis was performed for each acquisition protocol. RESULTS: Detection performances improved when passing from a short (ESD = 1 min) protocol to longer (ESD C 2 min) protocols. This improvement was established with adequate statistical significance. CONCLUSIONS: Short image acquisition times of 1 min/bed using 18F-FDG and the specific scanner model considered in the study lead to reduced lesion detectability and should be avoided also in underweight patients. |
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Authors:
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Roberta Matheoud; Lucia Leva; Chiara Secco; Gianmauro Sacchetti; Patrizia Della Monica; Marco Brambilla; Eugenio Inglese |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 25 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-06-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 179-88 Citation Subset: IM |
Affiliation:
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Medical Physics Department, AOU Maggiore della Carita, C.so Mazzini 18, 28100 Novara, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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