Document Detail

Small intestine large granular lymphoma in a horse.
MedLine Citation:
PMID:  11280380     Owner:  NLM     Status:  MEDLINE    
A 12-year-old Appaloosa gelding was referred to the Texas Veterinary Medical Center with a history of chronic diarrhea and weight loss. At necropsy, numerous oval, craterlike ulcers were observed throughout the small intestine. Histologically, these lesions were composed of a neoplastic proliferation of round cells with intracytoplasmic phosphotungstic acid-hematoxylin-positive granules. The tumor cells stained positively for the CD3 antigen and negatively for a B-cell marker. A diagnosis of large granular lymphoma was based on the morphologic and immunohistochemical characteristics of the neoplasm. The postmortem presentation of this case depicted unusual multifocal, ulcerative lymphomatous lesions throughout the small intestine without involvement of the regional lymph nodes. The histologic and ultrastructural morphology of the neoplastic lymphocytes was similar to that in previously reported cases of abdominal equine large granular lymphomas, but in this case the neoplasm was restricted to the small intestine.
P Herraez; B Berridge; P Marsh; B Weeks; F Ramiro-Ibañez
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  38     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-30     Completed Date:  2001-06-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  IM    
Department of Pathobiology, College of Veterinary Medicine, Texas A&M University, College Station 77843, USA.
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MeSH Terms
Fatal Outcome
Horse Diseases / pathology*
Immunohistochemistry / veterinary
Intestinal Mucosa / pathology
Intestinal Neoplasms / pathology,  veterinary*
Intestine, Small / pathology*
Lymphoma, Large B-Cell, Diffuse / pathology,  veterinary*
Microscopy, Electron / veterinary

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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