Document Detail

Small intestine bacterial overgrowth does not correspond to intestinal inflammation in cystic fibrosis.
MedLine Citation:
PMID:  20560844     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Small intestine bacterial overgrowth (SIBO) has been reported in cystic fibrosis (CF) patients. However, the potential link to intestinal inflammation has not been studied so far. Therefore, we aimed to assess whether SIBO correlates with intestinal inflammation in CF patients.
MATERIAL AND METHODS: As a preliminary study, we assessed whether calprotectin is detectable in sputum expectorated by 10 CF patients. Since significant immunoreactivity was documented, in the major study we have included exclusively CF subjects not expectorating sputum for at least two weeks. Fecal calprotectin was measured in 25 CF patients and 30 healthy subjects (HS). All CF subjects were tested for the presence of SIBO using the hydrogen-methane breath test (BT). According to obtained results CF patients were divided into SIBO positive and negative subgroups. Subsequently, the intensity of intestinal inflammation in both subgroups was compared.
RESULTS: Fecal calprotectin concentrations in CF patients (range: 1.8-302.5; median 80.0 mg/L) were significantly higher (p < 0.00001) than in HS (not detectable-15.5; 2.5 mg/L). Calprotectin levels were abnormal in 21 (84%) studied CF subjects and none of HS. Abnormal BT results were found in 10 (40.0%) of CF patients. Calprotectin concentrations in SIBO positive and negative patients did not differ.
CONCLUSIONS: Gastrointestinal inflammation is a frequent finding in cystic fibrosis patients. However, small intestine bacterial overgrowth does not seem to be the major or at least not the only determinant of intestinal inflammation. Indirect measures of intestinal inflammation in CF patients may give false positive results.
Aleksandra Lisowska; Edyta Madry; Andrzej Pogorzelski; Jarosław Szydłowski; Andrzej Radzikowski; Jarosław Walkowiak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  70     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-24     Completed Date:  2010-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  322-6     Citation Subset:  IM    
Department of Gastroenterology & Metabolism, Poznanń University of Medical Sciences, Poznań, Poland.
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MeSH Terms
Bacteria / growth & development
Blind Loop Syndrome / etiology
Breath Tests
Child, Preschool
Cystic Fibrosis / complications*,  microbiology,  pathology
False Positive Reactions
Feces / chemistry
Gastrointestinal Diseases / immunology
Inflammation / immunology*,  microbiology,  pathology
Intestine, Small / immunology,  microbiology*
Leukocyte L1 Antigen Complex / metabolism
Reg. No./Substance:
0/Leukocyte L1 Antigen Complex

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