Document Detail


Small intestinal segment perfusion test in piglets: future applications in studying probiotics-gut crosstalk in infectious diarrhoea?
MedLine Citation:
PMID:  21831782     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Worldwide infectious diarrhoea, mainly caused by rotavirus and enterotoxigenic Escherichia coli (ETEC), accounts for a large part of deaths in children. ETEC is also the main cause of traveller's diarrhoea. Probiotics are promising for prevention and treatment of diarrhoea, but there is insufficient evidence to support the use of any specific probiotic or probiotics in general. Because of the sensitivity of suckling and weaned piglets for ETEC, piglets are a good model for infectious diarrhoea in infants and traveller's diarrhoea. Just as in human the efficacy of probiotics in diminishing diarrhoea and improving growth in suckling and weaned piglets is not uniform. A piglet model of infectious diarrhoea provides access to intestinal compartments that are not easily accessible in infants. In an in situ piglet model of secretory diarrhoea, the functional physiological response to ETEC and the concomitant host genome response to ETEC and probiotics may be tested. This will provide new insights in the complex crosstalk between ETEC, probiotics and the gut in the future.
Authors:
J van der Meulen; M M Hulst; M A Smits; T Schuurman
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Beneficial microbes     Volume:  1     ISSN:  1876-2891     ISO Abbreviation:  Benef Microbes     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-08-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101507616     Medline TA:  Benef Microbes     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  439-45     Citation Subset:  IM    
Affiliation:
BioMedical Research of Wageningen UR, P.O. Box 65, 8200 AB Lelystad, the Netherlands.
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