| Small intestinal presentation of nodular lymphocyte-predominant Hodgkin lymphoma with T cell/histiocyte-rich B cell lymphoma-like areas-with review of literature on extranodal presentation of this disease. | |
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MedLine Citation:
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PMID: 21436871 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), accounts for ∼5% of all cases of Hodgkin lymphoma and is characterized by involvement of the peripheral lymph nodes. NLPHL occurs in young adults and is associated with frequent relapses. In 3% to 7% of cases, NLPHL progresses to a diffuse large B cell lymphoma. Furthermore, a proportion of NLPHL also have areas with features of T cell/histiocyte-rich large B cell lymphoma (THRLBCL), either at presentation or on follow-up. Here, we describe a 32-year-old man who presented to the emergency department with small bowel perforation. The resected small bowel showed full-thickness mural ulceration and involvement by a lymphoma with features of NLPHL that also had areas resembling THRLBCL. The patient had axillary lymphadenopathy, biopsy of which showed NLPHL with focal THRLBCL-like areas. Such a lymphoma presenting as small intestinal lesion/perforation has not been reported in the literature before. We take this opportunity to review the literature on extranodal presentations of NLPHL and discuss the natural history of this disease. |
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Authors:
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Izhar N Bagwan; Graham Knee; Zaid Abboudi; Kikkeri N Naresh |
Publication Detail:
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Type: Journal Article Date: 2010-03-24 |
Journal Detail:
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Title: Journal of hematopathology Volume: 3 ISSN: 1865-5785 ISO Abbreviation: J Hematop Publication Date: 2010 |
Date Detail:
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Created Date: 2011-03-25 Completed Date: 2011-07-14 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 101491976 Medline TA: J Hematop Country: Germany |
Other Details:
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Languages: eng Pagination: 29-34 Citation Subset: - |
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