| Small intestinal permeability to mannitol and lactulose in the three ethnic groups resident in west Birmingham. | |
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MedLine Citation:
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PMID: 8977337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: Asymptomatic residents of tropical countries have differences in small intestinal morphology and permeability compared with residents of temperate zones. The aim of this study was to investigate small intestinal permeability and morphology in three ethnic groups resident in Birmingham, UK. METHODS: 28 white patients, 101 Indian (Indian subcontinent), and 49 Afro-Caribbean adult patients with dyspepsia had endoscopic distal duodenal biopsies and a hyperosmolar lactulose/mannitol permeability test. Twenty normal white subjects had the permeability test. RESULTS: Lactulose/mannitol excretion ratios (LMER) were: white subjects 0.022 (median), white patients 0.022, Indians 0.031, Afro-Caribbeans 0.033. Differences between the immigrant groups and the two white groups were significant (p < 0.001); 33% of Indians and 45% of Afro-Caribbeans had LMER outside the range of the white groups. Afro-Caribbeans born in the UK had significantly lower LMER than those born abroad (p < 0.05); a similar trend was seen in Indians. Villous height/mucosal thickness ratios, calculated from small intestinal biopsy specimens, were lower in the immigrant groups and correlated inversely with LMER (r = 0.28; p < 0.05). Time resident in the tropics also correlated inversely with LMER. CONCLUSIONS: There were significant differences in small intestinal permeability and morphology between immigrants resident in a Western country and the native white population. The data suggested that these differences were related to environmental factors. |
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Authors:
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T H Iqbal; K O Lewis; J C Gearty; B T Cooper |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Gut Volume: 39 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1997-01-10 Completed Date: 1997-01-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 199-203 Citation Subset: AIM; IM |
Affiliation:
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Gastroenterology Unit, City Hospital, Birmingham. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult African Continental Ancestry Group Aged Biopsy Case-Control Studies Dyspepsia / ethnology*, pathology England / epidemiology European Continental Ancestry Group Female Humans Intestine, Small / metabolism, pathology* Lactulose / pharmacokinetics Male Mannitol / pharmacokinetics Middle Aged Permeability |
| Chemical | |
Reg. No./Substance:
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4618-18-2/Lactulose; 69-65-8/Mannitol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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