| Small intestinal mucins are secreted in proportion to the settling volume in water of dietary indigestible components in rats. | |
| | |
MedLine Citation:
|
PMID: 16177208 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to clarify the effect of dietary indigestible components on small intestinal mucin secretion. We prepared polystyrene foam (PSF) with different expansion ratios (PSF-30, -60 and -90) in which powders had different settling volumes in water (SV). Rats were fed a purified diet containing 0, 10, 30, or 90 g of PSF-60/kg for 10 d. After 8 h of food deprivation, rats were refed 3 g of their respective diets within 90 min. Small intestinal mucin fractions were prepared, and periodic acid/Schiff-reactive substances and O-linked oligosaccharide chains were determined as mucin markers. Feeding of PSF-60 increased the small intestinal mucin secretion dose dependently (control vs. 30 or 60 g of PSF-60/kg, P < 0.05). When rats were fed either purified diet or diets containing PSF-30, 60, or 90 at 10 g/kg for 7 d, small intestinal mucins were greatly affected by the SV of the respective PSF tested. Rats fed the diet containing PSF-90 with the highest SV had the highest amount of mucins (vs. control, P < 0.05). In some natural dietary fibers, the small intestinal mucins and SV were correlated (r = 0.967, P = 0.002). Finally, rats were fed a purified diet or that diet containing 50 g of PSF-60/kg for 7 d. Then, each dietary group was further divided into 2 groups. After 8 h of food deprivation, rats were refed 3 g of purified or PSF diet. Greater mucins in the small intestine were manifest only in rats previously fed the PSF diet whether they were refed purified or PSF diet (control vs. PSF, P < 0.05). These results suggest that the small intestinal mucins are secreted in proportion to the SV of dietary indigestible components, and chronic ingestion of indigestible components is required for the appearance of enhanced mucin secretion. |
| | |
Authors:
|
Hiroki Tanabe; Kimio Sugiyama; Tsukasa Matsuda; Shuhachi Kiriyama; Tatsuya Morita |
Related Documents
:
|
6772728 - Cholesterol absorption in baboons. 19854288 - The effect of peptide absorption on pept1 gene expression and digestive system hormones... 936958 - The influence of a chemical diet on the intestinal mucosa after jejuno-ileal bypass in ... 7066288 - Studies on the control of iron uptake by rabbit small intestine. 12211378 - Influence of macronutrients and activated charcoal on intake of sagebrush by sheep and ... 14558988 - Newer pharmaceutical agents to treat lipid disorders. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of nutrition Volume: 135 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-09-22 Completed Date: 2006-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 2431-7 Citation Subset: IM |
Affiliation:
|
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422-8529, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animal Feed Animals Dietary Fiber / pharmacology Digestion Intestinal Mucosa / metabolism*, secretion Intestine, Small / metabolism*, secretion Male Mucins / metabolism*, secretion Polystyrenes / pharmacology Rats Rats, Wistar Water / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Mucins; 0/Polystyrenes; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina pl...
Next Document: Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory c...