Document Detail


Small intestinal malabsorption in chronic alcoholism: a retrospective study of alcoholic patients by the ¹⁴C-D-xylose breath test.
MedLine Citation:
PMID:  22229732     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The ¹⁴C-D-xylose breath test was used at Ullevål University Hospital in the period from 1986 TO 1995 for malabsorption testing. The objective of this retrospective study was to reveal whether patients with chronic alcoholism may have intestinal malabsorption.
MATERIALS AND METHODS: The consecutive ¹⁴C-D-xylose breath test database was reviewed and patients with the diagnosis of chronic alcoholism were identified. ¹⁴C-D-xylose breath test results of the alcoholic patients were compared with the results of untreated celiac patients and patient and healthy controls. In the ¹⁴C-D-xylose breath test, ¹⁴C-D-xylose was dissolved in water and given orally after overnight fast. Breath samples were taken at 30-min intervals for 210 min, and ¹⁴CO₂ : ¹²CO₂ ratios were calculated for each time point, presenting a time curve for ¹⁴C-D-xylose absorption. Urine was collected after 210 min and the fraction of the total d-xylose passed was calculated (U%). ¹⁴CO₂ in breath and ¹⁴C-D-xylose in urine were analyzed using liquid scintillation.
RESULTS: Both breath and urine analysis revealed a pattern of malabsorption in alcoholics comparable with untreated celiac patients, with significantly reduced absorption of d-xylose compared with patient and healthy controls.
CONCLUSION: Alcoholic patients have a significantly reduced ¹⁴C-D-xylose absorption, comparable with untreated celiac patients. This indicates a reduced intestinal function in chronic alcoholism.
Authors:
Håvar Hope; Viggo Skar; Olav Sandstad; Einar Husebye; Asle W Medhus
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-10
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  47     ISSN:  1502-7708     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-20     Completed Date:  2012-07-26     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  England    
Other Details:
Languages:  eng     Pagination:  428-34     Citation Subset:  IM    
Affiliation:
Medical Department, Lovisenberg Diakonale Hospital, Oslo, Norway. blichhope@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Alcoholism / diagnosis*
Breath Tests / methods*
Carbon Dioxide / analysis
Case-Control Studies
Female
Humans
Intestinal Absorption / physiology
Intestine, Small / pathology*
Malabsorption Syndromes / diagnosis*
Male
Middle Aged
Retrospective Studies
Xylose / diagnostic use*,  urine
Young Adult
Chemical
Reg. No./Substance:
0/Xylose; 124-38-9/Carbon Dioxide
Comments/Corrections
Erratum In:
Scand J Gastroenterol. 2013 Oct;48(10):1231-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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