| Small intestinal malabsorption in chronic alcoholism: a retrospective study of alcoholic patients by the (14)C-d-xylose breath test. | |
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MedLine Citation:
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PMID: 22229732 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective. The (14)C-d-xylose breath test was used at Ullevål University Hospital in the period from 1986-1995 for malabsorption testing. The objective of this retrospective study was to reveal whether patients with chronic alcoholism may have intestinal malabsorption. Materials and methods. The consecutive (14)C-d-xylose breath test database was reviewed and patients with the diagnosis of chronic alcoholism were identified. (14)C-d-xylose breath test results of the alcoholic patients were compared with the results of untreated coeliac patients and patient and healthy controls. In the (14)C-d-xylose breath test, (14)C-d-xylose was dissolved in water and given orally after overnight fast. Breath samples were taken at 30-min intervals for 210 min, and (14)CO(2) : (12)CO(2) ratios were calculated for each time point, presenting a time curve for (14)C-d-xylose absorption. Urine was collected after 210 min and the fraction of the total d-xylose passed was calculated (U%). (14)CO(2) in breath and (14)C-d-xylose in urine were analyzed using liquid scintillation. Results. Both breath and urine analysis revealed a pattern of malabsorption in alcoholics comparable with untreated coeliac patients, with significantly reduced absorption of d-xylose compared with patient and healthy controls. Conclusion. Alcoholic patients have a significantly reduced (14)C-d-xylose absorption, comparable with untreated coeliac patients. This indicates a reduced intestinal function in chronic alcoholism. |
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Authors:
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Håvar B Hope; Viggo Skar; Olav Sandstad; Einar Husebye; Asle W Medhus |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-10 |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: - ISSN: 1502-7708 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medical Department, Lovisenberg Diakonale Hospital , Oslo , Norway. |
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