Document Detail

Small-intestinal and colonic changes after biliopancreatic bypass for morbid obesity.
MedLine Citation:
PMID:  3101167     Owner:  NLM     Status:  MEDLINE    
Morphologic and functional adaptations of the functioning intestine were evaluated in 41 patients before and after biliopancreatic bypass for morbid obesity. This surgical procedure diverts pancreatobiliary secretions via the duodenum and the jejunum into the colon, the remaining small intestine being anastomosed to the stomach after antrectomy. In the proximal ileum there was an 80% increase of the height of villi; the specific activities of maltase, sucrase, and aminopeptidase in brush border membranes remained unaffected, and that of lactase tended to decrease. In the distal ileum villi heights increased only by 58%, and disaccharidase activities (except for maltase) were slightly enhanced. In the colon the mucosa displayed, in some patients, focal appearance of true villi, and brush border enzyme activities increased concomitantly. We conclude that biliopancreatic bypass induces an adaptation of all intestinal segments of the functioning intestine; this adaptation tends to compensate for the shortening of the gut continuity.
C Stock-Damgé; M Aprahamian; F Raul; J Marescaux; N Scopinaro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  21     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1987-03-10     Completed Date:  1987-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  1115-23     Citation Subset:  IM    
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MeSH Terms
Biliary Tract / metabolism,  pathology
Biliary Tract Surgical Procedures*
Colon / pathology*
Intestine, Small / pathology*
Middle Aged
Obesity, Morbid / therapy*
Pancreas / metabolism,  pathology,  surgery*

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