Document Detail


Small intestinal atresia in a defined population: occurrence, prenatal diagnosis and survival.
MedLine Citation:
PMID:  17994616     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To describe the prevalence, associated anomalies, prenatal diagnosis, and survival of cases of congenital small intestinal atresia (SIA). METHOD: Data were extracted from the Northern Congenital Abnormality Survey (NorCAS) for cases delivered during 1991 to 2001. RESULTS: A total of 99 cases of SIA were notified from 372 717 registered births. Twenty-five (25.8%) SIA cases were associated with a chromosomal anomaly. Of the 72 SIA cases with normal karyotype, 18 (25%) were associated with other structural anomalies. The total prevalence for all SIA cases over the 11 years was 2.66 per 10 000 registered births (95% CI 2.13, 3.18), and the livebirth prevalence was 2.37 per 10 000 livebirths (95% CI 1.88, 2.87). For jejunoileal atresia, the total prevalence increased from 0.54 per 10 000 births during 1991-1995 to 1.11 per 10 000 births during 1996-2001, and livebirth prevalence increased from 0.49 to 1.06 per 10 000 livebirths. The more proximal the lesion the prenatal diagnosis sensitivity was slightly better with 19 (44.2%) cases of duodenal atresia and 3 (42.8%) cases of jejunal atresia diagnosed prenatally by routine ultrasonography. CONCLUSION: This population-based study of SIA has confirmed several previous findings but, by considering subtypes separately, it also suggests a trend towards an increase in the prevalence of jejunoileal atresia (JIA).
Authors:
Victoria Hemming; Judith Rankin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  27     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  1205-11     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 John Wiley & Sons, Ltd.
Affiliation:
Foundation Programme Doctor, University Hospital of North Durham, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
England / epidemiology
Female
Humans
Intestinal Atresia / complications,  epidemiology,  ultrasonography*
Live Birth / epidemiology*
Male
Pregnancy
Prevalence
Prognosis
Registries
Retrospective Studies
Stillbirth / epidemiology*
Survival Analysis
Ultrasonography, Prenatal / statistics & numerical data*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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