Document Detail

Small-for-gestational-age preterm-born infants already have lower bone mass during early infancy.
MedLine Citation:
PMID:  22750451     Owner:  NLM     Status:  Publisher    
BACKGROUND: In preterm-born infants, low birth weight and diminished bone accretion deteriorate peak bone mass. Whether low birth weight is already associated with decreased bone mass during infancy is unknown. OBJECTIVE: To study the effect of birth weight on bone accretion between term age (40weeks postmenstrual age) and six months post-term in preterm-born infants. DESIGN: In 139 preterm-born infants (51% male, gestational age 30.3±1.5weeks, birth weight 1341±288 gram) weight and whole-body bone mineral content (BMC, gram) were measured at term age and six months post-term. At birth, infants were small-for-gestational-age (SGA, n=33, weight and/or length<-2 SDS) or appropriate-for-gestational-age (AGA, n=98, weight and length≥-2 SDS). RESULTS: At term age and six months post-term, BMC adjusted for gender and gestational age was lower in SGA than AGA infants (term age: 38.1±9.5 versus 48.6±10.1 gram, β=-0.26, 95%CI -0.37;-0.16, p<0.001; six months: 130.1±25.7 versus 145.4±22.9 gram, β=-0.16, 95%CI -0.25;-0.08, p<0.001). At six months post-term, BMC remained lower in SGA infants after adjustment for actual weight and length. Between term age and six months post-term, BMC gain adjusted for gender and gestational age was lower in SGA than AGA infants (91.7±22.8 versus 98.2±20.7 gram; β=-0.12, 95%CI -0.24;-0.003, p=0.044). BMC gain remained lower in SGA infants after adjustment for weight and length gain. CONCLUSION: The first six months post-term, SGA preterms have lower bone accretion, independent of body size, suggesting that prenatal conditions for bone accretion cannot be replicated postnatally.
Monique van de Lagemaat; Joost Rotteveel; Mirjam M van Weissenbruch; Harrie N Lafeber
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-28
Journal Detail:
Title:  Bone     Volume:  -     ISSN:  1873-2763     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-7-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
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