Document Detail

Small for gestational age infant in association with maternal prothrombin gene variant (nt 20210A).
MedLine Citation:
PMID:  10391523     Owner:  NLM     Status:  MEDLINE    
Most of disproportionate infants born small for gestational age (SGA) have an history of placental dysfunction with no explained cause. We report a case of an unexplained SGA infant with placental infarctions and thrombosis. Maternal thrombophilic disorder tests revealed that the patient was heterozygous for the A20210 prothrombin gene variant a newly identified thrombotic risk factor. It may be suggest that prothrombin gene variant, as factor V Leiden, could be a genetic risk factor for placental insufficiency.
E Verspyck; V Le Cam-Duchez; A Gravier; G Descargues; L Marpeau; J Y Borg
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  83     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-28     Completed Date:  1999-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  143-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Rouen University Hospital, France.
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MeSH Terms
Fetal Growth Retardation / etiology*
Infant, Newborn
Infant, Small for Gestational Age*
Placenta / blood supply
Placental Insufficiency / complications,  genetics*
Polymerase Chain Reaction
Pregnancy Complications, Hematologic / physiopathology*
Prothrombin / genetics*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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