| Small for gestational age infant in association with maternal prothrombin gene variant (nt 20210A). | |
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MedLine Citation:
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PMID: 10391523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most of disproportionate infants born small for gestational age (SGA) have an history of placental dysfunction with no explained cause. We report a case of an unexplained SGA infant with placental infarctions and thrombosis. Maternal thrombophilic disorder tests revealed that the patient was heterozygous for the A20210 prothrombin gene variant a newly identified thrombotic risk factor. It may be suggest that prothrombin gene variant, as factor V Leiden, could be a genetic risk factor for placental insufficiency. |
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Authors:
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E Verspyck; V Le Cam-Duchez; A Gravier; G Descargues; L Marpeau; J Y Borg |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 83 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-07-28 Completed Date: 1999-07-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 143-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Rouen University Hospital, France. eric.verspyck@chu-rouen.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Growth Retardation / etiology* Heterozygote Humans Infant, Newborn Infant, Small for Gestational Age* Infarction Placenta / blood supply Placental Insufficiency / complications, genetics* Polymerase Chain Reaction Pregnancy Pregnancy Complications, Hematologic / physiopathology* Prothrombin / genetics* Thrombosis |
| Chemical | |
Reg. No./Substance:
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9001-26-7/Prothrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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