Document Detail


Small for gestational age (SGA) neonates show reduced suppressive activity of their regulatory T cells.
MedLine Citation:
PMID:  19837002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Little information exists concerning the role of fetal regulatory T cells (Tregs) during intrauterine development. We examined whether complications such as reduced birth weight or the occurrence of preterm labor were associated with deficiencies in the number or in the immunosuppressive activity of Tregs in the fetal circulation. Their total number did not change during normal or complicated pregnancy. In contrast, their level of FoxP3 expression decreased continuously with gestational age and was significantly reduced in the presence of spontaneous term, but not preterm labor. In small for gestational age (SGA) neonates, FoxP3 expression was constantly decreased when compared to age matched healthy neonates. In accordance with the low FoxP3 expression, the suppressive activity of the Tregs from spontaneously term delivered and from SGA babies was significantly reduced. We propose that the level of FoxP3 expression in the fetal Tregs may be a potential regulator of their suppressive activity.
Authors:
Andrea Steinborn; Martina Engst; Gertrud Maria Haensch; Karsten Mahnke; Edgar Schmitt; Stefan Meuer; Christof Sohn
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-26
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  134     ISSN:  1521-7035     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-04     Completed Date:  2010-03-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-97     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, University of Heidelberg, Voss-Strasse 9, 69115 Heidelberg, Germany. andrea.steinborn@med.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Cell Separation
Female
Fetus / immunology
Flow Cytometry
Forkhead Transcription Factors / immunology*
Humans
Infant, Low Birth Weight / blood,  immunology*
Infant, Newborn / immunology*
Obstetric Labor, Premature
Pregnancy
T-Lymphocyte Subsets / immunology*
T-Lymphocytes, Regulatory / immunology*
Chemical
Reg. No./Substance:
0/FOXP3 protein, human; 0/Forkhead Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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