| Small fibre dysfunction, microvascular complications and glycaemic control in type 1 diabetes: a case-control study. | |
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MedLine Citation:
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PMID: 22193513 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS/HYPOTHESIS: The aim of this study was to determine the influence of microvascular disease on C-fibre function in patients with type 1 diabetes of moderate duration. METHODS: The axon-reflex flare area induced on the dorsum of the foot by local skin heating to 47°C was measured with a laser Doppler imager (LDI) in sex-, age- and height-matched groups with type 1 diabetes, with and without microvascular disease (MV+ and MV-, respectively) and in healthy controls (HC). Each group consisted of 24 individuals and all were free from clinical neuropathy (neuropathy disability score <3 and Toronto clinical neuropathy score <5). RESULTS: LDI flare (LDIflare) was reduced in MV+ compared with HC (5.1 ± 1.8 vs 10.0 ± 3.1 cm(2), p < 0.0001) and MV- groups (9.9 ± 2.9 cm(2), p < 0.0001). MV- and HC groups did not differ. There was no difference in diabetes duration between MV- and MV+ groups (17.5 ± 5.7 and 20.1 ± 5.2 years, p = 0.21) nor current HbA(1c) (MV- 8.0 ± 1.2% [64 ± 10 mmol/mol]; MV+ 8.0 ± 0.9% [64 ± 9 mmol/mol], p = 0.53); neither variable correlated with flare size. In contrast, duration-averaged HbA(1c) was higher in the MV+ group (8.6 ± 0.9% [70 ± 9 mmol/mol] vs 7.6 ± 0.6% [60 ± 7 mmol/mol], p < 0.001) and correlated with LDIflare size (r = -0.50, p < 0.001). Triacylglycerols were higher in MV+ compared with MV- (1.23 ± 0.121 vs 0.93 ± 0.7 mmol/l, p = 0.04), but other metabolic variables did not differ between the groups. CONCLUSIONS/INTERPRETATION: We have shown that glycaemic burden and the presence of microvascular complications are associated with small fibre dysfunction in type 1 diabetes. |
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Authors:
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P R J Vas; A Q Green; G Rayman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-23 |
Journal Detail:
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Title: Diabetologia Volume: - ISSN: 1432-0428 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006777 Medline TA: Diabetologia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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The Diabetes Research Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich, Suffolk, IP4 5PD, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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