Document Detail

Small cell neuroendocrine carcinoma of the urinary bladder: report on two cases and review of the literature.
MedLine Citation:
PMID:  20549899     Owner:  NLM     Status:  MEDLINE    
Small cell (Neuroendocrine) carcinoma of the urinary bladder is a rare but highly aggressive malignancy. The neoplastic cells exhibit both neuroendocrine and epithelial differentiation. It is morphologically indistinguishable from the more common pulmonary small cell carcinoma. It can occur either in association with urothelial (transitional cell) carcinoma or in a pure form. Presenting signs and symptoms are non specific. Histologically, it can mimic poorly differentiated urothelial carcinoma and lymphoma. Muscle invasion is almost invariably present at diagnosis and mortality is mainly due to metastases rather than loco regional recurrence. The optimal therapeutic modality is still controversial. In this article, we report on two cases occurring in a pure form and we briefly review the published literature regarding the clinical presentation, morphology, differential diagnosis, prognosis and treatment.
Camil J Chouairy; Ali N Salloum; George Y Ghazal
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Le Journal médical libanais. The Lebanese medical journal     Volume:  58     ISSN:  0023-9852     ISO Abbreviation:  J Med Liban     Publication Date:    2010 Apr-Jun
Date Detail:
Created Date:  2010-06-16     Completed Date:  2010-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375352     Medline TA:  J Med Liban     Country:  Lebanon    
Other Details:
Languages:  eng     Pagination:  111-9     Citation Subset:  IM    
Department of Pathology, St George Hospital University Medical Center, Achrafieh, Beirut, Lebanon.
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MeSH Terms
Aged, 80 and over
Carcinoma, Neuroendocrine / pathology*,  surgery
Urinary Bladder Neoplasms / pathology*,  surgery

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