| Small cell (neuroendocrine) carcinoma of the prostate: etiology, diagnosis, prognosis, and therapeutic implications--a retrospective study of 30 patients from the rare cancer network. | |
| | |
MedLine Citation:
|
PMID: 19092321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Within the framework of the Rare Cancer Network Study, we examined 30 patients suffering from small cell neuroendocrine prostate cancer, either in an early/localized or an advanced/metastatic stage. Patients were treated with cisplatin-based chemotherapy, with or without pelvic radiotherapy. Two patients with early disease achieved complete remission for a duration of 19 and 22 months. Three patients with advanced disease achieved complete remission for 6, 7, and 54 months, respectively. Twenty-five patients succumbed to massive local and/or distant failure. No patient presented with brain metastases as the initial site of relapse. Small cell neuroendocrine prostate carcinoma is a very aggressive disease with a poor prognosis, even in its localized form. Despite initial response, the common cisplatin-based chemotherapy plus radiotherapy failed to improve outcome markedly. Improvement will come from understanding the biology of the disease and integrating new targeted therapies into the treatment of this rare and aggressive tumor. |
| | |
Authors:
|
Moshe E Stein; Zvi Bernstein; Ufuc Abacioglu; Meric Sengoz; Robert C Miller; Amichai Meirovitz; Abadou Zouhair; Salvador Villà Freixa; Philip H Poortmans; Robert Ash; Abraham Kuten |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of the medical sciences Volume: 336 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-12-18 Completed Date: 2009-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
|
Languages: eng Pagination: 478-88 Citation Subset: AIM; IM |
Affiliation:
|
Northern Israel Oncology Center, Rambam Health Care Campus, Faculty of Medicine, Haifa, Israel. m_stein@rambam.health.gov.il |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Carcinoma, Small Cell / etiology*, pathology, physiopathology, therapy* Diagnosis, Differential* Humans Male Middle Aged Neoplasm Metastasis Prognosis Prostatic Neoplasms / etiology*, pathology, physiopathology, therapy* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Fat embolism syndrome.
Next Document: Causes and consequences of systemic venous hypertension.