| Small-cell lung carcinoma: an analysis of 194 consecutive patients. | |
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MedLine Citation:
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PMID: 9708628 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The treatment of small-cell lung carcinoma (SCLC) requires the careful combination of chemotherapy and radiation therapy. To understand the factors involved in the outcome of these patients, the authors undertook a study of patients treated for limited stage SCLC. The charts of 194 consecutive patients treated at our facilities between 1986 and 1994 were reviewed. All patients underwent thoracic radiation therapy (TRT), 50% received prophylactic cranial irradiation (PCI), and all but one received chemotherapy. The probability of survival at 5 years was 14%, and the disease-free survival (DFS) was 17%. Patients receiving a combination of platinum and etoposide (PE) and Cytoxan (Bristol-Myers, Evansville, IN, U.S.A.), Adriamycin (Adria Laboratories, Dublin, OH, U.S.A.), and Vincristine (Eli Lilly, Indianapolis, IN, U.S.A.) (CAV) experienced a DFS at 3 years of 31%, versus 14% for CAV only and 18% for PE only (p = 0.004). In a multivariate survival analysis, only PCI (p = 0.001), having received PE and CAV (p = 0.01), and response to treatment (p = 0.001) were significant. Radiation dose and field size did not influence outcome. The combination of PE and CAV chemotherapy produced the best results in our series. Unanswered questions regarding the optimal TRT dose, field size, and timing of TRT await the results of ongoing randomized trials. |
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Authors:
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D E Dosoretz; J H Rubenstein; M J Katin; P H Blitzer; S A Reisinger; G R Garton; S A Salenius; W H Harwin; T E Teufel; M G Raymond; J A Reeves; M S Rubin; L L Hart; M J McCleod; A Pizarro; A L Gabarda |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical oncology Volume: 21 ISSN: 0277-3732 ISO Abbreviation: Am. J. Clin. Oncol. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-08-27 Completed Date: 1998-08-27 Revised Date: 2006-04-24 |
Medline Journal Info:
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Nlm Unique ID: 8207754 Medline TA: Am J Clin Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 333-7 Citation Subset: IM |
Affiliation:
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Radiation Therapy Regional Center, Fort Meyers, FL 33908, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use Carcinoma, Small Cell / drug therapy*, radiotherapy* Combined Modality Therapy Cranial Irradiation Female Humans Lung Neoplasms / drug therapy*, radiotherapy* Male Middle Aged Multivariate Analysis Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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