Document Detail

Small cell carcinomas of the gastrointestinal tract: clinicopathological features and treatment approach.
MedLine Citation:
PMID:  17270665     Owner:  NLM     Status:  MEDLINE    
Small cell undifferentiated carcinoma (SmCC) of the gastrointestinal tract (GIT) is a rare and highly aggressive malignancy. To date, fewer than 1,000 cases have been reported, with an estimated prevalence of 0.1% to 1% of all gastrointestinal (GI) tumors. Data on the disease are scarce due to its rarity and the fact that most authors have focused on one site within the GIT. In light of the limited data and its perceived similarity to SmCC of the lung, the disease has usually been treated as the latter. Nevertheless, recent clinicopathologic and molecular data imply several differences between the two entities, questioning the extent to which extrapolations from one to the other can be made. We review the available data on GI SmCC with emphasis on outlining its clinicopathologic features and the recommended treatment approach.
Baruch Brenner; Laura H Tang; Jinruh Shia; David S Klimstra; David P Kelsen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in oncology     Volume:  34     ISSN:  0093-7754     ISO Abbreviation:  Semin. Oncol.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-02     Completed Date:  2007-03-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0420432     Medline TA:  Semin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-50     Citation Subset:  IM    
Institute of Oncology, Rabin Medical Center, Beilinson Campus, Petach Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Carcinoma, Small Cell / diagnosis,  epidemiology,  genetics,  pathology*,  therapy*
Combined Modality Therapy
Gastrointestinal Neoplasms / diagnosis,  epidemiology,  genetics,  pathology*,  therapy*
Neoplasm Staging

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