Document Detail

Small cell carcinoma of the lung: serum calcitonin and serum histaminase (diamine oxidase) at basal levels and stimulated by pentagastrin.
MedLine Citation:
PMID:  211804     Owner:  NLM     Status:  MEDLINE    
Investigations were performed to evaluate the incidence of increased serum calcitonin and histaminase in 79 patients with untreated small cell carcinoma of the lung (SSC). In addition, serum calcitonin was measured following pentagastrin stimulation in 19 of these patients. Serum calcitonin was elevated in 54 of 79 patients (68%), 20 patients (25%) having a level usually associated with the diagnosis of medullary carcinoma of the thyroid (MCT). The levels of histaminase, on the other hand, did not differ from the distribution in normals. In three of 19 patients undergoing the pentagastrin stimulation test, calcitonin was significantly increased. Thus, serum calcitonin is frequently elevated in patients with SCC and a positive pentagastrin test is not pathognomonic of MCT.
M Hansen; H H Hansen; N Tryding
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Scandinavica     Volume:  204     ISSN:  0001-6101     ISO Abbreviation:  Acta Med Scand     Publication Date:  1978  
Date Detail:
Created Date:  1978-12-02     Completed Date:  1978-12-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370330     Medline TA:  Acta Med Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  257-61     Citation Subset:  IM    
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MeSH Terms
Amine Oxidase (Copper-Containing) / blood*
Calcitonin / blood*,  secretion
Carcinoma, Small Cell / blood*,  secretion
Hormones, Ectopic / secretion
Lung Neoplasms / blood*,  secretion
Pentagastrin / diagnostic use*
Stimulation, Chemical
Reg. No./Substance:
0/Hormones, Ectopic; 5534-95-2/Pentagastrin; 9007-12-9/Calcitonin; EC Oxidase (Copper-Containing)

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