| Small cell carcinoma of the gallbladder combined with adenocarcinoma. | |
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MedLine Citation:
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PMID: 1664637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A rare case of small cell carcinoma (SCC) of the gallbladder combined with adenocarcinoma is reported. The patient was a 70-year-old Japanese man, who died of the disease shortly after the onset of symptoms. Autopsy disclosed a small tumor (1.0 cm in longest diameter) in the fundus of the gallbladder, with widespread metastasis. Histochemically, the tumor cells showed negative reactions for argyrophilic and argentaffin stainings, a weak immunohistochemical reaction only for neuron-specific enolase, and negative reactions for all of the other neurosecretory markers used, including neurofilament, chromogranin, somatostatin, gastrin and leu-7. However, electron microscopic examination revealed a few typical neurosecretory granules (NSG) in the cytoplasm of some tumor cells. We suggest that: 1. The presence of NSG in the cytoplasm of tumor cells is the most reliable diagnostic criterion for SCC. 2. SCC, at least the combined type, arises from a multipotential stem cell. |
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Authors:
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H J Duan; H Ishigame; Z Ishii; N Itoh; H Shigematsu |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Acta pathologica japonica Volume: 41 ISSN: 0001-6632 ISO Abbreviation: Acta Pathol. Jpn. Publication Date: 1991 Nov |
Date Detail:
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Created Date: 1992-03-17 Completed Date: 1992-03-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372637 Medline TA: Acta Pathol Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 841-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Shinshu University School of Medicine, Nagano, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
/
chemistry,
complications*,
diagnosis Aged Autopsy Carcinoma, Small Cell / chemistry, complications*, diagnosis Cytoplasmic Granules / ultrastructure Gallbladder Neoplasms / chemistry, complications*, diagnosis Humans Immunohistochemistry Male Microscopy, Electron Phosphopyruvate Hydratase / analysis |
| Chemical | |
Reg. No./Substance:
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EC 4.2.1.11/Phosphopyruvate Hydratase |
| Comments/Corrections | |
Erratum In:
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Acta Pathol Jpn 1991 Dec;41(12):following 932 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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