Document Detail

Small-cell carcinoma of the endometrium presenting as Cushing's syndrome.
MedLine Citation:
PMID:  19834252     Owner:  NLM     Status:  MEDLINE    
Small-cell carcinoma (SCC) of neuroendocrine type is an uncommon tumor of the endometrium. No previous report has documented Cushing's syndrome due to ectopic ACTH production by SCC of the endometrium. We describe a 56-year-old Japanese woman with SCC of the endometrium and multiple lung metastases presenting as Cushing's syndrome. The patient was referred to our hospital because of general fatigue with facial and leg edema, and multiple nodular lesions in the bilateral lungs on chest X-ray examination. A physical examination revealed that the patient had moon face, buffalo hump, and truncal obesity. Endocrinological examinations confirmed ACTH-dependent Cushing's syndrome. Thoracic computed tomography imaging showed multiple nodular lesions in the bilateral lungs. Abdominal magnetic resonance imaging suggested a malignant tumor of the uterus. The patient received a lung tumor biopsy and surgical hysterectomy. The endometrial carcinoma was histologically a SCC admixed with endometrioid adenocarcinoma. The SCC of the endometrium showed immunoreactivity for pro-opiomelanocortin, ACTH, and vimentin, but not for thyroid transcription factor-1. The lung biopsy specimen had the same features. These findings indicated that the SCC originated from the endometrium, and the ectopic ACTH-producing tumor caused Cushing's syndrome. This study provides the evidence that SCC of endometrial origin was an ectopic ACTH-producing tumor causing Cushing's syndrome.
Haruhiro Sato; Genta Kanai; Hiroshi Kajiwara; Johbu Itoh; Robert Yoshiyuki Osamura
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-10-16
Journal Detail:
Title:  Endocrine journal     Volume:  57     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  31-8     Citation Subset:  IM    
Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan.
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MeSH Terms
Carcinoma, Small Cell / complications*,  diagnosis,  surgery
Cushing Syndrome / diagnosis,  etiology*
Diagnosis, Differential
Endometrial Neoplasms / complications*,  diagnosis,  surgery
Fatal Outcome
Magnetic Resonance Imaging
Middle Aged
Tomography, X-Ray Computed

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