Document Detail

Small-bowel permeability in collagenous colitis.
MedLine Citation:
PMID:  16938717     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Collagenous colitis (CC) is a chronic inflammatory bowel disease that affects the colon. However, some patients with CC present with accompanying pathologic small-bowel manifestations such as coeliac disease, defects in bile acid absorption and histopathologic changes in small-intestinal biopsies, indicating that CC is a pan-intestinal disease. In small-intestinal disease, the intestinal barrier function may be impaired, and the permeability of the small intestine altered. The purpose of this research was to study small-bowel function in patients with CC as expressed by intestinal permeability. MATERIAL AND METHODS: Ten patients with CC and chronic diarrhoea participated in the study. Coeliac disease was excluded by small-bowel biopsy and/or serology. Intestinal permeability was assessed as urinary excretion (ratios) 2, 4 and 6 h after ingestion of 14C-labelled mannitol (14C-mannitol) and 99mTc-labelled diethylenetriamine-pentaacetic acid (99mTc-DTPA). Data were compared with the results from healthy controls. RESULTS: No difference was found between groups in urinary excretion of 14C-mannitol and 99mTc-DTPA after 2, 4 or 6 h, respectively. Likewise, no significant differences in the 99mTc-DTPA/14C-mannitol ratios between patients and controls were detected after 2 h: 0.030 (0.008-0.130) versus 0.020 (0.007-0.030), p = 0.19, after 4 h: 0.040 (0.009-0.180) versus 0.020 (0.008-0.040), p = 0.14 or after 6 h: 0.040 (0.012-0.180) versus 0.020 (0.010-0.040), p = 0.17. CONCLUSIONS: No alterations in intestinal permeability in patients with CC could be demonstrated. Impairment of the integrity of the mucosa of the small bowel and the presence of a general dysfunction of the small intestine in patients with CC seem unlikely.
Signe Wildt; Jan L Madsen; Jüri J Rumessen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of gastroenterology     Volume:  41     ISSN:  0036-5521     ISO Abbreviation:  Scand. J. Gastroenterol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-29     Completed Date:  2006-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0060105     Medline TA:  Scand J Gastroenterol     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1044-9     Citation Subset:  IM    
Department of Gastroenterology, University Hospital of Copenhagen, Denmark.
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MeSH Terms
Carbon Radioisotopes / diagnostic use,  pharmacokinetics*,  urine
Colitis, Collagenous / metabolism*,  radionuclide imaging
Follow-Up Studies
Intestine, Small / metabolism*,  pathology,  radionuclide imaging
Mannitol / diagnostic use,  pharmacokinetics*,  urine
Middle Aged
Severity of Illness Index
Technetium Tc 99m Pentetate / diagnostic use,  pharmacokinetics*,  urine
Reg. No./Substance:
0/Carbon Radioisotopes; 65454-61-7/Technetium Tc 99m Pentetate; 69-65-8/Mannitol

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