| Small-bowel permeability in collagenous colitis. | |
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MedLine Citation:
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PMID: 16938717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Collagenous colitis (CC) is a chronic inflammatory bowel disease that affects the colon. However, some patients with CC present with accompanying pathologic small-bowel manifestations such as coeliac disease, defects in bile acid absorption and histopathologic changes in small-intestinal biopsies, indicating that CC is a pan-intestinal disease. In small-intestinal disease, the intestinal barrier function may be impaired, and the permeability of the small intestine altered. The purpose of this research was to study small-bowel function in patients with CC as expressed by intestinal permeability. MATERIAL AND METHODS: Ten patients with CC and chronic diarrhoea participated in the study. Coeliac disease was excluded by small-bowel biopsy and/or serology. Intestinal permeability was assessed as urinary excretion (ratios) 2, 4 and 6 h after ingestion of 14C-labelled mannitol (14C-mannitol) and 99mTc-labelled diethylenetriamine-pentaacetic acid (99mTc-DTPA). Data were compared with the results from healthy controls. RESULTS: No difference was found between groups in urinary excretion of 14C-mannitol and 99mTc-DTPA after 2, 4 or 6 h, respectively. Likewise, no significant differences in the 99mTc-DTPA/14C-mannitol ratios between patients and controls were detected after 2 h: 0.030 (0.008-0.130) versus 0.020 (0.007-0.030), p = 0.19, after 4 h: 0.040 (0.009-0.180) versus 0.020 (0.008-0.040), p = 0.14 or after 6 h: 0.040 (0.012-0.180) versus 0.020 (0.010-0.040), p = 0.17. CONCLUSIONS: No alterations in intestinal permeability in patients with CC could be demonstrated. Impairment of the integrity of the mucosa of the small bowel and the presence of a general dysfunction of the small intestine in patients with CC seem unlikely. |
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Authors:
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Signe Wildt; Jan L Madsen; Jüri J Rumessen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of gastroenterology Volume: 41 ISSN: 0036-5521 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-29 Completed Date: 2006-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
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Languages: eng Pagination: 1044-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, University Hospital of Copenhagen, Denmark. siw@dadlnet.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Carbon Radioisotopes / diagnostic use, pharmacokinetics*, urine Colitis, Collagenous / metabolism*, radionuclide imaging Female Follow-Up Studies Humans Intestine, Small / metabolism*, pathology, radionuclide imaging Male Mannitol / diagnostic use, pharmacokinetics*, urine Middle Aged Permeability Severity of Illness Index Technetium Tc 99m Pentetate / diagnostic use, pharmacokinetics*, urine |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 65454-61-7/Technetium Tc 99m Pentetate; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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