Document Detail

Small-bowel diagnosis in patients with familial adenomatous polyposis: comparison of push enteroscopy, capsule endoscopy, ileoscopy, and enteroclysis.
MedLine Citation:
PMID:  19358059     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Conventional upper endoscopy (EGD), EGD with side-view endoscope and ileoscopy are established procedures for endoscopic evaluation of patients with familial adenomatous polyposis (FAP). However, we still have little data on the frequency and relevance of adenomas in those parts of the small bowel which are not accessible to EGD and ileoscopy. Adenomas distal to the duodenum are found more often in FAP patients with known duodenal adenomas. The question is, whether these patients can benefit from additional endoscopic and/or radiographic examinations. METHODS: Between July 2001 and August 2006 we performed comparative small bowel studies with push enteroscopy (PE), capsule endoscopy (CE), ileoscopy (IL) and enteroclysis (EC) in 25 FAP patients known to have duodenal adenomas. The number, size and location of any adenomas detected were documented. RESULTS: PE: The examination revealed duodenal adenomas (max. size 80 mm) requiring treatment in 9 of the 25 patients examined. In 12 of the 25 patients the PE showed adenomas distal to the ligament of Treitz with a maximum size of 15 mm. CE: In 22 of the 23 examined patients the CE revealed adenomas of the small bowel. Thirteen of these 22 patients also had adenomas in regions not accessible to PE or IL. These adenomas had a maximum size of 10 mm. IL: In 12 of the 25 patients adenomas were found in the region of the ileal pouch. The maximum size of the adenomas was 10 mm. EC: In 19 of the 23 examined patients the EC examination produced a false-negative result. in 8 of these 19 patients the adenomas not detected radiologically measured >or= 10 mm. CONCLUSIONS: FAP patients with duodenal adenomas particularly often have adenomas distal to the duodenum. CE is a safe and convenient method for evaluating the small bowel in these patients. EC is considerably inferior to the endoscopic procedures for evaluation of the small bowel and is therefore not suitable for the diagnosis of adenomas in FAP.
N Plum; A May; H Manner; C Ell
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-04-08
Journal Detail:
Title:  Zeitschrift für Gastroenterologie     Volume:  47     ISSN:  0044-2771     ISO Abbreviation:  Z Gastroenterol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-09     Completed Date:  2009-06-26     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0033370     Medline TA:  Z Gastroenterol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  339-46     Citation Subset:  IM    
Dept. of Internal Medicine II, HSK Wiesbaden, Teaching Hospital of the University of Mainz, Germany.
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MeSH Terms
Adenomatous Polyposis Coli / diagnosis*,  pathology
Barium Sulfate / diagnostic use*
Capsule Endoscopy*
Cell Transformation, Neoplastic / pathology
Contrast Media*
Duodenum / pathology
Endoscopy, Gastrointestinal*
Intestine, Small* / pathology
Intubation, Gastrointestinal
Jejunum / pathology
Middle Aged
Sensitivity and Specificity
Young Adult
Reg. No./Substance:
0/Contrast Media; 7727-43-7/Barium Sulfate

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