Document Detail


Small bowel carcinoma revealing HNPCC syndrome.
MedLine Citation:
PMID:  20627638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small bowel adenocarcinoma is a rare condition with poor prognosis. Like colorectal cancer, small bowel carcinoma may be a part of genetic syndromes with carcinogenetic pathways different from sporadic forms. We report a case of 41-year-old man with small bowel carcinoma revealing hereditary non polyposis colorectal cancer (HNPCC) syndrome. This report supports the systematic study of the MSI status in every patient with a small bowel carcinoma below 60-year-old of age in order to screen for HNPCC syndrome even in the absence of a family history of related cancers.
Authors:
T Babba; O Schischmanoff; C Lagorce; P Wind; G Des Guetz; T Aparicio; R Benamouzig
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Gastroentérologie clinique et biologique     Volume:  34     ISSN:  2210-7401     ISO Abbreviation:  Gastroenterol. Clin. Biol.     Publication Date:    2010 Apr-May
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704825     Medline TA:  Gastroenterol Clin Biol     Country:  France    
Other Details:
Languages:  eng     Pagination:  325-8     Citation Subset:  IM    
Affiliation:
Service de Gastroentérologie, Hôpital Avicenne, 125, rue de Stalingrad, 93009 Bobigny cedex, France. thouraya.babba@avc.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Signal Transducing / genetics
Adenocarcinoma / pathology*,  therapy
Adult
Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis*
Duodenal Neoplasms / pathology*,  therapy
Exons
Humans
Male
Mutation
Nuclear Proteins / genetics
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/MLH1 protein, human; 0/Nuclear Proteins

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