| Small bowel bacterial overgrowth and type 1 diabetes. | |
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MedLine Citation:
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PMID: 20085122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gastrointestinal motility disorders are often present in diabetic patients (pts). Such motility dysfunctions have been attributed to autonomic neuropathy. Impaired intestinal motility is often associated with small-bowel bacterial overgrowth (SIBO) but only few studies evaluated the relationship between autonomic neuropathy and SIBO in diabetic pts. AIM: To compare the prevalence of SIBO between type 1 diabetic (T1D) pts with and without autonomic neuropathy. PATIENTS AND METHODS: 25 pts (13 males, 12 females; mean age 44.2+/-7) affected by type 1 diabetes with normal cardiovascular autonomic test (group A) and 25 type 1 diabetic pts with abnormal cardiovascular autonomic test (group B) were submitted to hydrogen lactulose breath test. RESULTS: 2 out of 25 (8%) showed SIBO among group A, while 11 out of 25 (44%) showed SIBO among group B (p<0.01). Interestingly, among group B, the daily insulin requirements was significantly higher in SIBO-positive pts compared to SIBO-negative: 0.66+/-0.3 vs. 0.59+/-0.1 UI/kg (p<0.05). CONCLUSIONS: Pts with autonomic neuropathy have a significantly higher prevalence of SIBO, that is also associated with a higher daily insulin requirements. |
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Authors:
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V Ojetti; D Pitocco; E Scarpellini; F Zaccardi; F Scaldaferri; G Gigante; G Gasbarrini; G Ghirlanda; A Gasbarrini |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European review for medical and pharmacological sciences Volume: 13 ISSN: 1128-3602 ISO Abbreviation: Eur Rev Med Pharmacol Sci Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2010-01-20 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717360 Medline TA: Eur Rev Med Pharmacol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 419-23 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy. veronica.ojetti@tin.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bacteria / growth & development* Diabetes Mellitus, Type 1 / complications* Diabetic Neuropathies / complications*, diagnosis Female Humans Intestinal Diseases / complications, epidemiology*, microbiology Intestine, Small / microbiology* Male Middle Aged |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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