Document Detail

Small bowel adaptation with growth hormone and glutamine after massive resection of rat's small bowel.
MedLine Citation:
PMID:  10364785     Owner:  NLM     Status:  MEDLINE    
The use of glutamine (GLN) and growth hormone (GH) improves intestinal adaptation in short bowel syndrome (SBS). The present study aimed to assess the effect of a diet rich in glutamine and the use of GH on intestinal adaptation in experimental SBS. 80 Wistar rats (240 g) were randomized into 6 groups: 1) RGLN (20)--95% small bowel resection and fed on GLN diet; 2) RGLNGH (20)--95% SBR, GLN diet and GH; 3) RC (10)--95% SBR and fed on a low GLN control diet (C); 4) RCGH (10)--95% SBR and C diet and GH; 5) TAGLIN (10)--intestinal transection and anastomosis (Ta) and fed on a GLN diet; 6) TAGLNGH (10)--Ta and GLN diet and GH. GH was given SC at a dose of 0.14 mg/kg/day. The rats were weighed daily and nitrogen balance was made. Rats were sacrificed after 15 days and mucosa cell proliferation was studied with PC10 antibody. Statistical analysis was performed. All SBR rats lost weight as compared to their initial weight (8% to 13%). GH improved Ta rats weight (18.98 x 5.04%). The use of GLN diet and GH improved nitrogen balance and bowel growth on SBR groups, as compared to controls, but not cell proliferation. In conclusion, the use of GLN enriched diet and GH improves intestinal adaptation after massive resection of the small bowel in rats.
D L Waitzberg; C Cukier; D R Mucerino; A F Logulo; R S Torrinhas; I de Castro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Nutrición hospitalaria     Volume:  14     ISSN:  0212-1611     ISO Abbreviation:  Nutr Hosp     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-06-24     Completed Date:  1999-06-24     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9100365     Medline TA:  Nutr Hosp     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  81-90     Citation Subset:  IM    
Surgery Department of the School of Medicine of the São Paulo University, Brasil.
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MeSH Terms
Disease Models, Animal
Glutamine / administration & dosage*,  pharmacology
Human Growth Hormone / administration & dosage*,  pharmacology
Rats, Wistar
Short Bowel Syndrome / drug therapy*
Reg. No./Substance:
12629-01-5/Human Growth Hormone; 56-85-9/Glutamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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