| Small-bowel absorption of D-tagatose and related effects on carbohydrate digestibility: an ileostomy study. | |
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MedLine Citation:
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PMID: 11124758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The ketohexose D-tagatose is a new sweetener with a low energy content. This low energy content may be due to either low absorption of the D-tagatose or decreased absorption of other nutrients. OBJECTIVE: The aims of this study were to measure the excretion of D-tagatose from the human small bowel, to calculate the apparent absorption of D-tagatose, and to study the effects of D-tagatose on the small-bowel excretion of other carbohydrates. DESIGN: A controlled diet was served for 2 periods of 2 d during 3 consecutive weeks to 6 ileostomy subjects. In one of the periods, 15 g D-tagatose was added to the diet daily. Duplicate portions of the diet and ileostomy effluents were freeze-dried and analyzed to calculate the apparent net absorption of D-tagatose and carbohydrates. RESULTS: Median D-tagatose excretion was 19% (range: 12-31%), which corresponded to a calculated apparent absorption of 81% (69-88%). Of the total amount of D-tagatose excreted [2.8 g (1.7-4.4 g)], 60% (8-88%) was excreted within 3 h. Between 3 and 5 h, 32% (11-82%) was excreted. Excretion of wet matter increased by 41% (24-52%) with D-tagatose ingestion. Sucrose and D-glucose excretion increased to a small extent, whereas no significant changes were found in the excretion of dry matter, energy, starch, or D-fructose. CONCLUSIONS: The apparent absorption of 15 g D-tagatose/d was 81%. D-Tagatose had only a minor influence on the apparent absorption of other nutrients. |
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Authors:
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L Normén; H N Laerke; B B Jensen; A M Langkilde; H Andersson |
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Publication Detail:
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Type: Clinical Trial; Evaluation Studies; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 73 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-10 Completed Date: 2001-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 105-10 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Nutrition, Göteborg University, Göteborg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Calorimetry Chromatography, High Pressure Liquid Dietary Carbohydrates / metabolism*, pharmacokinetics Digestion Feces / chemistry Female Gastrointestinal Transit* Hexoses / metabolism, pharmacokinetics*, pharmacology Humans Ileostomy Intestinal Absorption* / drug effects Male Middle Aged Sweetening Agents / metabolism, pharmacokinetics*, pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Hexoses; 0/Sweetening Agents; 17598-81-1/tagatose |
| Comments/Corrections | |
Erratum In:
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Am J Clin Nutr 2001 Mar;73(3):665 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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