Document Detail


Small birth weight does not compromise ventilatory chemosensitivity in the 1-day old hatchling.
MedLine Citation:
PMID:  20478415     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sustained hypoxia is known to decrease embryonic growth and to lower the newborn's ventilatory chemosensitivity (VCS) to hypoxia and hypercapnia. What was unclear is whether or not a difference in birth weight could per se, and independently from hypoxia, have some influence on the magnitude of VCS. VCS, defined as the relative increase in ventilation-oxygen consumption ratio (V(E)/V(O2)), was studied by a modification of the barometric technique in 1-day old chicken hatchlings born at term and selected for large differences in birth weight. The small hatchlings (SM, 35.9+/-0.7 g) had smaller V(O2) and V(E) than the large hatchlings (LG, 47.0+/-0.6 g), both in air and during acute exposures to hypoxia (15% or 10% O(2)) or hypercapnia (2% or 4% CO(2)). However, when normalized by the air values, the metabolic and ventilatory responses coincided. Values of V(E)/V(O2) in air, hypoxia or hypercapnia were the same in SM and LG, and much higher than those previously measured in hatchlings with prenatal hypoxia. It is concluded that (a) birth weight per se does not affect V(E) chemosensitivity, and (b) the blunting effects of hypoxia on body growth and chemosensitivity are parallel events, and the former does not contribute to the latter.
Authors:
Jacopo P Mortola
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Publication Detail:
Type:  Journal Article     Date:  2010-05-15
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  172     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  206-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Physiology, McGill University, Montreal, Quebec, Canada. jacopo.mortola@mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / physiology*
Anoxia / metabolism
Birth Weight / physiology*
Carbon Dioxide / metabolism
Chick Embryo
Chickens / physiology*
Hypercapnia / metabolism
Oxygen Consumption / physiology*
Respiratory Mechanics / physiology
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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