| Small birth weight does not compromise ventilatory chemosensitivity in the 1-day old hatchling. | |
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MedLine Citation:
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PMID: 20478415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sustained hypoxia is known to decrease embryonic growth and to lower the newborn's ventilatory chemosensitivity (VCS) to hypoxia and hypercapnia. What was unclear is whether or not a difference in birth weight could per se, and independently from hypoxia, have some influence on the magnitude of VCS. VCS, defined as the relative increase in ventilation-oxygen consumption ratio (V(E)/V(O2)), was studied by a modification of the barometric technique in 1-day old chicken hatchlings born at term and selected for large differences in birth weight. The small hatchlings (SM, 35.9+/-0.7 g) had smaller V(O2) and V(E) than the large hatchlings (LG, 47.0+/-0.6 g), both in air and during acute exposures to hypoxia (15% or 10% O(2)) or hypercapnia (2% or 4% CO(2)). However, when normalized by the air values, the metabolic and ventilatory responses coincided. Values of V(E)/V(O2) in air, hypoxia or hypercapnia were the same in SM and LG, and much higher than those previously measured in hatchlings with prenatal hypoxia. It is concluded that (a) birth weight per se does not affect V(E) chemosensitivity, and (b) the blunting effects of hypoxia on body growth and chemosensitivity are parallel events, and the former does not contribute to the latter. |
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Authors:
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Jacopo P Mortola |
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Publication Detail:
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Type: Journal Article Date: 2010-05-15 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 172 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 206-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Physiology, McGill University, Montreal, Quebec, Canada. jacopo.mortola@mcgill.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Anoxia / metabolism Birth Weight / physiology* Carbon Dioxide / metabolism Chick Embryo Chickens / physiology* Hypercapnia / metabolism Oxygen Consumption / physiology* Respiratory Mechanics / physiology |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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