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Small biparietal diameter of fetuses with spina bifida at the 11-13 week scan and at midgestation.
MedLine Citation:
PMID:  22511513     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: To assess whether at ultrasound scan at 11-13 weeks' gestation and in mid-trimester the biparietal diameter (BPD) in fetuses with open spina bifida is smaller than the reference range. Patients: In a multicenter retrospective analysis of data from 23 fetuses with open spina bifida diagnosed at 16-24 weeks, BPD at mid-gestation was compared to BPD measured at 11-13 weeks, when diagnosis was not known. Z-scores were calculated for comparison of BPD deviations within the groups and at both time intervals. Results: BPD z-scores at 11-13 weeks and 16-24 weeks were significantly lower (p<0.0001) in fetuses with open spina bifida when compared to the reference range, with mean values of -1.29 and -2.14 respectively, corresponding to the 10th and 1.5th centile respectively. Interestingly, at 11-13 weeks only 6/23 (26%) fetuses with open spina bifida were below the 5th centile in comparison to 16/23 (69%) of the same group at mid-gestation. This was confirmed by the paired t-test comparing both measurements at the first and second visits showing significantly slower growth of the BPD in spina bifida. Conclusions: In fetuses with open spina bifida, BPD is smaller not only in the second trimester as previously known, but also in the first trimester. This is most likely due to loss of cerebrospinal fluid. We suggest that a BPD value below the 10th centile in an otherwise normally grown fetus at 11-13 weeks' gestation should be considered as a potential subtle early marker for open spina bifida. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
K Karl; B Benoit; M Entezami; K S Heling; R Chaoui
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Department of Obstetrics and Gynecology, Maistrasse, Ludwig-Maximilians-University, Munich, Germany.
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