Document Detail


Small animal model for myocardial infarction.
MedLine Citation:
PMID:  925909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial infarctions were produced in rats by electro-cauterization of the left anterior descending artery, and the extent of myocardial damage was measured by serial serum levels of creatine phosphokinase activity utilizing spectrophotometric analysis. All animals were also evaluated for myocardial damage by electrocardiographic wave alterations. A correlation between myocardial infarct size and serum creatine phosphokinase was demonstrated. Significant arrhythmias and death occurred only in experimental groups where myocardial infarction had been produced. This small animal model offers a quick, inexpensive, and simple method for screening therapeutic agents that alter infarct size.
Authors:
R J Staab; V de Paul Lynch; C Lau-Cam; M Barletta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  66     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1977 Oct 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1483-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Creatine Kinase / blood
Disease Models, Animal
Electrocardiography
Heart Rate
Male
Methods
Myocardial Infarction / enzymology,  physiopathology*
Rats
Time Factors
Chemical
Reg. No./Substance:
EC 2.7.3.2/Creatine Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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