Document Detail

Small airway morphology and lung function in the transition from normality to chronic airway obstruction.
MedLine Citation:
PMID:  12598485     Owner:  NLM     Status:  MEDLINE    
This study investigated the relationships between pathological changes in small airways (<6 mm perimeter) and lung function in 22 nonasthmatic subjects (20 smokers) undergoing lung resection for peripheral lesions. Preoperative pulmonary function tests revealed airway obstruction [ratio of forced expiratory volume in 1 s to forced vital capacity (FEV1/FVC) < 70%] in 12 subjects and normal lung function in 10. When all subjects were considered together, total airway wall thickness was significantly correlated with FEV1/FVC (r2 = 0.25), reactivity to methacholine (r2 = 0.26), and slope of linear regression of FVC against FEV1 values recorded during the methacholine challenge (r2 = 0.56). Loss of peribronchiolar alveolar attachments was significantly associated (r2 = 0.25) with a bronchoconstrictor effect of deep inhalation, as assessed from a maximal-to-partial expiratory flow ratio <1, but not with airway responses to methacholine. No significant correlation was found between airway smooth muscle thickness and lung function measurements. In conclusion, this study suggests that thickening of the airway wall is a major mechanism for airway closure, whereas loss of airway-to-lung interdependence may contribute to the bronchoconstrictor effect of deep inhalation in the transition from normal lung function to airway obstruction in nonasthmatic smokers.
Angelo Corsico; Manlio Milanese; Simonetta Baraldo; Gian Luca Casoni; Alberto Papi; Anna Maria Riccio; Isa Cerveri; Marina Saetta; Vito Brusasco
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-02-21
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  95     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-09     Completed Date:  2004-02-02     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  441-7; discussion 435     Citation Subset:  IM    
Dipartimento di Medicina Interna, Università di Genova, 16132 Genova, Italy.
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MeSH Terms
Bronchi / pathology,  physiopathology*
Bronchial Hyperreactivity / metabolism*,  physiopathology*
Forced Expiratory Volume / physiology
Lung / pathology,  physiopathology*
Methacholine Chloride / pharmacology
Muscarinic Agonists / pharmacology
Pulmonary Disease, Chronic Obstructive / pathology,  physiopathology*
Respiratory Mechanics / physiology
Vital Capacity / physiology
Reg. No./Substance:
0/Muscarinic Agonists; 62-51-1/Methacholine Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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