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Small airway dysfunction is associated to excessive bronchoconstriction in asthmatic patients.
MedLine Citation:
PMID:  25158694     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BackgroundWe investigated whether a relationship between small airways dysfunction and bronchial hyperresponsiveness (BHR), expressed both in terms of ease of airway narrowing and of excessive bronchoconstriction, could be demonstrated in asthma.Methods63 (36 F; mean age 42 yr¿±¿14) stable, mild-to-moderate asthmatic patients (FEV1 92% pred ±14; FEV1/FVC 75%¿±¿8) underwent the methacholine challenge test (MCT). The degree of BHR was expressed as PD20 (in ¿g) and as ¿FVC%. Peripheral airway resistance was measured pre- and post-MCT by impulse oscillometry system (IOS) and expressed as R5-R20 (in kPa sL¿1).ResultsAll patients showed BHR to methacholine (PD20 <¿1600 ¿g) with a PD20 geometric (95% CI) mean value of 181(132¿249) ¿g and a ¿FVC% mean value of 13.6%¿±¿5.1, ranging 2.5 to 29.5%. 30 out of 63 patients had R5-R20 >¿0.03 kPa sL¿1 (>upper normal limit) and showed ¿FVC%, but not PD20 values significantly different from the 33 patients who had R5-R20¿¿¿0.03 kPa sL¿1 (15.8%¿±¿4.6 vs 11.5%¿±¿4.8, p <¿0.01 and 156(96¿254) ¿g vs 207 (134¿322) ¿g, p =¿0.382). In addition, ¿FVC% values were significantly related to the corresponding pre- (r =¿0.451, p <¿0.001) and post-MCT (r =¿0.376, p <¿0.01) R5-R20 values.ConclusionsOur results show that in asthmatic patients, small airway dysfunction, as assessed by IOS, is strictly associated to BHR, expressed as excessive bronchoconstriction, but not as ease of airway narrowing.
Authors:
Veronica Alfieri; Marina Aiello; Roberta Pisi; Panagiota Tzani; Elisa Mariani; Emilio Marangio; Dario Olivieri; Gabriele Nicolini; Alfredo Chetta
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-27
Journal Detail:
Title:  Respiratory research     Volume:  15     ISSN:  1465-993X     ISO Abbreviation:  Respir. Res.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101090633     Medline TA:  Respir Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  86     Citation Subset:  -    
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