Document Detail


Small RNAs - secrets and surprises of the genome.
MedLine Citation:
PMID:  20409269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small RNAs associated with post-transcriptional gene silencing were first discovered in plants in 1999. Although this study marked the beginning of small RNA biology in plants, the sequence of the Arabidopsis genome and related genomic resources that were soon to become available to the Arabidopsis community launched the research on small RNAs at a remarkable pace. In 2000, when the genetic blueprint of the first plant species was revealed, the tens of thousands of endogenous small RNA species as we know today remained hidden features of the genome. However, the subsequent 10 years have witnessed an explosion of our knowledge of endogenous small RNAs: their widespread existence, diversity, biogenesis, mode of action and biological functions. As key sequence-specific regulators of gene expression in the nucleus and the cytoplasm, small RNAs influence almost all aspects of plant biology. Because of the extensive conservation of mechanisms concerning the biogenesis and molecular actions of small RNAs, research in the model plant Arabidopsis has contributed vital knowledge to the small RNA field in general. Our knowledge of small RNAs gained primarily from Arabidopsis has also led to the invention of effective gene knock-down technologies that are applicable to diverse plant species, including crop plants. Here, I attempt to recount the developments of the small RNA field in the pre- and post-genomic era, in celebration of the 10th anniversary of the completion of the first plant genome.
Authors:
Xuemei Chen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  The Plant journal : for cell and molecular biology     Volume:  61     ISSN:  1365-313X     ISO Abbreviation:  Plant J.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-06-15     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  9207397     Medline TA:  Plant J     Country:  England    
Other Details:
Languages:  eng     Pagination:  941-58     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Arabidopsis / genetics*
Genome, Plant*
RNA Interference
RNA, Plant / genetics*
RNA, Small Interfering / genetics
Grant Support
ID/Acronym/Agency:
GM61146/GM/NIGMS NIH HHS; R01 GM061146/GM/NIGMS NIH HHS; R01 GM061146-12/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Plant; 0/RNA, Small Interfering
Comments/Corrections

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