| Small RNA-directed transcriptional control: New insights into mechanisms and therapeutic applications. | |
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MedLine Citation:
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PMID: 20519954 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The discovery of RNA interference (RNAi) has opened new avenues in biology and medicine. In addition to post-transcriptional gene silencing, new findings are expanding the range of action of small duplex RNAs and broadening the spectrum of the potential applications of RNAi-based therapeutics. In recent years a complex and heterogeneous network of non-protein coding RNAs (ncRNAs) with potential regulatory functions has come into the spotlight providing an unexpected perspective on the mechanisms of transcriptional and epigenetic control of gene expression in human cells. The spread and complexity of these RNA-based transcriptional regulatory networks are still to be explored. However, they are likely to be important mechanisms controlling gene expression in human cells. As we will learn more about these processes, endogenous small RNAs and ncRNAs participating in these transcriptional regulatory networks might become valuable targets to modulate expression of genes involved in human diseases. Thus, understanding these basic processes of gene regulation might be translated in the near future into innovative therapeutic strategies to treat human diseases. |
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Authors:
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Chiara Pastori; Marco Magistri; Sara Napoli; Giuseppina M Carbone; Carlo V Catapano |
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Publication Detail:
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Type: Journal Article Date: 2010-06-15 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 9 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2011-05-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2353-62 Citation Subset: IM |
Affiliation:
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Oncology Institute of Southern Switzerland; Bellinzona, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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