Document Detail


A Small Molecule Promotes Mitochondrial Fusion in Mammalian Cells.
MedLine Citation:
PMID:  22907892     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mitochondrial dynamics: An image-based screen identified a small molecule, M1, that specifically promotes the fusion of fragmented mitochondria and protects cells from mitochondrial-fragmentation-associated cell death. Mechanistic studies revealed that M1 shifts the mitochondrial dynamic balance towards fusion.
Authors:
Danling Wang; Jianing Wang; Ghislain M C Bonamy; Shelly Meeusen; Richard G Brusch; Carolina Turk; Pengyu Yang; Peter G Schultz
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Department of Chemistry, the Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA) http://schultz.scripps.edu/
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