Document Detail

Small molecule inhibitors of acid sphingomyelinase.
MedLine Citation:
PMID:  20501999     Owner:  NLM     Status:  MEDLINE    
Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An increasing set of data on the inhibition of acid sphingomyelinase in different disease models using indirect inhibitors has been generated and strongly implies acid sphingomyelinase as an emerging drug target. Very recently, some new and promising inhibitors from different substance classes have been developed. In this review, previous and current developments in the field are summarized.
Christoph Arenz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-05-18
Journal Detail:
Title:  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology     Volume:  26     ISSN:  1421-9778     ISO Abbreviation:  Cell. Physiol. Biochem.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-09-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9113221     Medline TA:  Cell Physiol Biochem     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Institut für Chemie, Humboldt Universität zu Berlin, Berlin, Germany.
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MeSH Terms
Cell Membrane / chemistry,  metabolism
Phosphates / chemistry
Phosphodiesterase Inhibitors / chemistry*,  pharmacology
Sphingomyelin Phosphodiesterase / antagonists & inhibitors*,  metabolism
Reg. No./Substance:
0/Phosphates; 0/Phosphodiesterase Inhibitors; EC Phosphodiesterase

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