| Small molecule inhibitors of acid sphingomyelinase. | |
| | |
MedLine Citation:
|
PMID: 20501999 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Despite of the importance of the acid sphingomyelinase for sphingomyelin homeostasis and sphingolipid signalling, potent and selective inhibitors for this enzyme are rare. An increasing set of data on the inhibition of acid sphingomyelinase in different disease models using indirect inhibitors has been generated and strongly implies acid sphingomyelinase as an emerging drug target. Very recently, some new and promising inhibitors from different substance classes have been developed. In this review, previous and current developments in the field are summarized. |
| | |
Authors:
|
Christoph Arenz |
Related Documents
:
|
845879 - Dibenz[b,e]oxepinalkanoic acids as nonsteroidal antiinflammatory agents. 2. dihydro-10-... 9371239 - Betidamino acid scan of the gnrh antagonist acyline. 20035849 - Measurement and prediction of solubilities of active pharmaceutical ingredients. 11382149 - Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of p450 17 (17 alp... 20527969 - Design, synthesis, and structure-activity relationship studies of novel 2,4,6-trisubsti... 11805219 - Pharmacological characterization of sc-57461a (3-[methyl[3-[4-(phenylmethyl)phenoxy]pro... 9681959 - Kainic acid induction of heme oxygenase in vivo and in vitro. 1721919 - Monoclonal antibodies to leishmania mexicana promastigote antigens. i. secreted acid ph... 1320229 - The response of gfr to amino acids differs between autosomal dominant polycystic kidney... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-05-18 |
Journal Detail:
|
Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology Volume: 26 ISSN: 1421-9778 ISO Abbreviation: Cell. Physiol. Biochem. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-05-26 Completed Date: 2010-09-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9113221 Medline TA: Cell Physiol Biochem Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 1-8 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 S. Karger AG, Basel. |
Affiliation:
|
Institut für Chemie, Humboldt Universität zu Berlin, Berlin, Germany. christoph.arenz@chemie.hu-berlin.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Membrane
/
chemistry,
metabolism Phosphates / chemistry Phosphodiesterase Inhibitors / chemistry*, pharmacology Sphingomyelin Phosphodiesterase / antagonists & inhibitors*, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Phosphates; 0/Phosphodiesterase Inhibitors; EC 3.1.4.12/Sphingomyelin Phosphodiesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Efficacy of novel oral formulations of alpha/beta arteether against multidrug-resistant malaria in m...
Next Document: Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs wit...