| Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. | |
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MedLine Citation:
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PMID: 17624948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukocyte-function-associated antigen-1 (LFA-1) is an integrin that is critical for T-cell adhesion and immunologic responses. As a transmembrane receptor and adhesion molecule, LFA-1 signals bidirectionally, whereby information about extracellular ligands is passed outside-in while cellular activation is transmitted inside-out to the adhesive ectodomain. Here, we review the role of small guanosine triphosphatases (GTPases) in LFA-1 signaling. Rap1, a Ras-related GTPase, appears to be central to LFA-1 function. Rap1 is regulated by receptor signaling [e.g. T-cell receptor (TCR), CD28, and cytotoxic T-lymphocyte antigen-4 (CTLA-4)] and by adapter proteins [e.g. adhesion and degranulation-promoting adapter protein (ADAP) and Src kinase-associated phosphoprotein of 55 kDa (SKAP-55)]. Inside-out signaling flows through Rap1 to regulator of adhesion and cell polarization enriched in lymphoid tissues (RAPL) and Rap1-GTP interacting adapter molecule (RIAM) that act in conjunction with the cytoskeleton on the cytosolic domain of LFA-1 to increase adhesion of the ectodomain. Outside-in signaling also relies on small GTPases such as Rho proteins. Vav-1, a guanine nucleotide exchange factor for Rho proteins, is activated as a consequence of LFA-1 engagement. Jun-activating binding protein-1 (JAB-1) and cytohesin-1 have been implicated as possible outside-in signaling intermediates. We have recently shown that Ras is also downstream of LFA-1 engagement: LFA-1 signaling through phospholipase D (PLD) to RasGRP1 was required for Ras activation on the plasma membrane following stimulation of TCR. |
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Authors:
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Adam Mor; Michael L Dustin; Mark R Philips |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Immunological reviews Volume: 218 ISSN: 0105-2896 ISO Abbreviation: Immunol. Rev. Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-07-12 Completed Date: 2007-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: Denmark |
Other Details:
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Languages: eng Pagination: 114-25 Citation Subset: IM |
Affiliation:
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Department of Medicine, NYU School of Medicine, New York, NY 10016, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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metabolism Animals Cell Adhesion Humans Lymphocyte Function-Associated Antigen-1 / immunology*, metabolism* Models, Immunological Monomeric GTP-Binding Proteins / immunology*, metabolism* Signal Transduction / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/Lymphocyte Function-Associated Antigen-1; EC 3.6.5.2/Monomeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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