Document Detail

Small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia: a case report and literature review.
MedLine Citation:
PMID:  20405240     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Gallbladder carcinoma has been associated with various paraneoplastic syndromes. These may be the presenting manifestations that lead the clinician to a diagnosis.
CASE REPORT: We report a case of small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia. The hyponatremia was further exacerbated by platinum-based chemotherapy.
DISCUSSION: There have previously been no reports of paraneoplastic hyponatremia in gallbladder carcinoma. We discuss the management of this problem and also provide a short literature review on the other paraneoplastic syndromes associated with gallbladder carcinoma.
CONCLUSION: Symptoms and signs of gallbladder cancer may be insidious. Thorough workup is needed if the patient presents with symptoms and signs of a paraneoplastic syndrome.
Esther S Ng; Kotamma Venkateswaran; Shridhar I Ganpathi; Benjamin Y Chuah
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of gastrointestinal cancer     Volume:  41     ISSN:  1941-6636     ISO Abbreviation:  J Gastrointest Cancer     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-19     Completed Date:  2011-02-17     Revised Date:  2012-09-07    
Medline Journal Info:
Nlm Unique ID:  101479627     Medline TA:  J Gastrointest Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-8     Citation Subset:  IM    
Department of Medicine, National University Health System, Singapore, Singapore.
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MeSH Terms
Carcinoma, Small Cell / complications,  pathology*
Gallbladder Neoplasms / complications,  pathology*
Hyponatremia / etiology*,  pathology*
Paraneoplastic Syndromes / etiology,  pathology*

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