Document Detail


"Smad"eningly erratic: target gene methylation determines whether TGFbeta promotes or suppresses malignant glioma.
MedLine Citation:
PMID:  17336898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
TGFbeta functions as a tumor suppressor in some contexts and a tumor promoter in others. In a recent issue of Cancer Cell, Bruna et al. (2007) shed light on an epigenetic mechanism that underlies this schizophrenic behavior in malignant glioma. Their findings highlight a stem cell/cancer link...and a potential blind spot in large-scale cancer genome sequencing projects.
Authors:
Santosh Kesari; Laurie Jackson-Grusby; Charles D Stiles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental cell     Volume:  12     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-05     Completed Date:  2007-04-27     Revised Date:  2013-10-30    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  324-5     Citation Subset:  IM    
Affiliation:
Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Neoplasms / genetics*,  metabolism,  physiopathology
Cell Transformation, Neoplastic / genetics,  metabolism
DNA Methylation*
Epigenesis, Genetic / genetics
Gene Expression Regulation, Neoplastic / genetics*
Glioma / genetics*,  metabolism,  physiopathology
Humans
Smad Proteins / genetics*,  metabolism
Stem Cells / metabolism
Transforming Growth Factor beta / genetics*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 HD050760/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Smad Proteins; 0/Transforming Growth Factor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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