| Smad4 disruption accelerates keratinocyte reepithelialization in murine cutaneous wound repair. | |
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MedLine Citation:
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PMID: 22644379 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Keratinocyte reepithelialization is a rate-limiting event in cutaneous wound repair, which involves the migration and proliferation of keratinocytes to cover the denuded dermal surface. Transforming growth factor-β1 (TGF-β1) has the ability to induce epithelial cell migration while inhibiting proliferation, and controversial results have been generated regarding the effect of TGF-β signaling on reepithelialization. In this study, full-thickness skin wounds were made in keratinocyte-specific Smad4 knockout and the control mice. The wound closure, reepithelialization, keratinocyte proliferation, myofibroblast numbers and collagen deposition of were assessed. The results showed that the proliferation of keratinocytes increased, which accelerated the reepithelialization, and led to faster wound repair in the epidermis of Smad4 mutant mice. Upregulation of keratin 17, 14-3-3 sigma and phosphorylated AKT in the hyperproliferative epidermis may be correlated with the accelerated reepithelialization. We conclude that Smad4 plays an inhibitory role in the keratinocyte-mediated reepithelialization of wound healing. |
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Authors:
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Leilei Yang; Wenlong Li; Shaoxia Wang; Lijuan Wang; Yang Li; Xiao Yang; Ruiyun Peng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-30 |
Journal Detail:
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Title: Histochemistry and cell biology Volume: - ISSN: 1432-119X ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506663 Medline TA: Histochem Cell Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Beijing Institute of Radiation Medicine, 27 Tai-ping Road, Beijing, 100850, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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