Document Detail


Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI.
MedLine Citation:
PMID:  22791656     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Tako-Tsubo cardiomyopathy (TTC) is associated with regional left ventricular dysfunction, independent of the presence of fixed coronary artery disease. Previous studies have used T2-weighted cardiac MRI to demonstrate the presence of periapical oedema. The authors sought to determine the distribution, resolution and correlates of oedema in TTC. PATIENTS: 32 patients with TTC were evaluated at a median of 2 days after presentation, along with 10 age-matched female controls. Extent of oedema was quantified both regionally and globally; scanning was repeated in patients with TTC after 3 months. Correlations were sought between oedema and the extent of hypokinesis, catecholamine release, release of N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), and markers of systemic inflammatory activation (high-sensitivity C-reactive protein and platelet response to nitric oxide). RESULTS: In the acute phase of TTC, T2-weighted signal intensity was greater at the apex than at the base (p<0.0001) but was nevertheless significantly elevated at the base (p<0.0001), relative to control values. Over 3 months, T2-weighted signal decreased substantially, but remained abnormally elevated (p<0.02). The regional extent of oedema correlated inversely with radial myocardial strain (except at the apex). There were also direct correlations between global T2-weighted signal and (1) plasma normetanephrine (r=0.39, p=0.04) and (2) peak NT-proBNP (r=0.39, p=0.03), but not with systemic inflammatory markers. CONCLUSIONS: TTC is associated with slowly resolving global myocardial oedema, the acute extent of which correlates with regional contractile disturbance and acute release of both catecholamines and NT-proBNP.
Authors:
Christopher Neil; Thanh Ha Nguyen; Angela Kucia; Benjamin Crouch; Aaron Sverdlov; Yuliy Chirkov; Gnanadevan Mahadavan; Joseph Selvanayagam; Dana Dawson; John Beltrame; Christopher Zeitz; Steven Unger; Thomas Redpath; Michael Frenneaux; John Horowitz
Related Documents :
15302806 - Effects of cardiac resynchronization therapy on myocardial perfusion reserve.
22555756 - Multiple gene polymorphisms predisposing to the prothrombotic state in an adolescent wi...
19163016 - Comparison of the electrophysiologically based optimization methods with different paci...
21742086 - Ischemic heart disease: comprehensive evaluation by cardiovascular magnetic resonance.
19442946 - Abnormal glucose metabolism in acute myocardial infarction: influence on left ventricul...
9591766 - Mitral regurgitation: impaired systolic function, eccentric hypertrophy, and increased ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-11
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  -     ISSN:  1468-201X     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Adelaide, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of thoracic epidural analgesia on clinical outcomes following transapical transcatheter aorti...
Next Document:  Aldosterone antagonists improve ejection fraction and functional capacity independently of functiona...